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[18] Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P.A., Drucker, D.J. 2003. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478. [19] Park, S., Dong, X., Fisher, T.L., Dunn, S., Omer, A.K., Weir, G., et al...
1.The aim of this project is to establish a GLP-1 signaling pathway targeted cell model, for screening the new class of GLP-1 receptor agonists as anti-diabetic candidates.建立以GLP-1信号通路为靶点的药物筛选细胞模型,用于筛选GLP-1受体激动剂类的新型抗糖尿病药物。
F.K., Sposito, A.C. Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonis...
2.1.2噻唑烷二酮类 过氧化物酶体增殖物激活受体 γ( peroxisome proliferator-activated receptor-γ,PPAR-γ)是一个调节脂肪代谢和炎性反应的转录因子,被激活后可导致脂肪组织对非酯化脂肪酸的摄取增加,脂肪组织的脂肪合成增加,使体内脂肪分布从肝脏转移到脂肪组织,减轻了肝脏脂毒性。它还可调节脂肪组织释放细胞因子...
To explore the role of activation of glucagon-like peptide 1 receptor (GLP-1R) and its relative cell signaling pathway in the cytoprotection of geniposide.Cell viability was determined by MTT assay. Knockdown of the Glp-1r gene was carried out with shRNA. The levels of HO-1 protein and ...