Interestingly, sitagliptin administration activated the glucagon-like peptide-1 (GLP-1)/GLP-1 receptor (GLP-1R) pathway by increasing the expression of GLP-1 and GLP-1R in a rat model of FS. Moreover, administration of the GLP-1R inhibitor exendin9-39 increased seizure severity, and ...
A.C. Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists. Cardiovasc Diabe...
Furthermore, APS significantly increased the expressions of GLP-1 and STRs signaling molecules in the pancreas of T2DM rats, as well as the expression of GLP-1 receptor signaling molecules. Conversely, APS remarkably decreased the expressions of GLUT2 and KCNJ11 in the pancreas of T2DM rats. ...
Woodman, O.L., et al. 2010. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug ...
www.nature.com/scientificreports OPEN Topography of the GLP‑1/GLP‑1 receptor system in the spinal cord of male mice Yvette Ruska 1, Andrea Csibi 1, Beáta Dorogházi 2, Anett Szilvásy‑Szabó 1, Petra Mohácsik 2, Zsuzsanna Környei 3, ...
[18] Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P.A., Drucker, D.J. 2003. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478. [19] Park, S., Dong, X., Fi...
13 Thus, the signaling pathway that is activated through the binding of the GLP-1 receptor agonists to the GLP-1 receptors can reduce inflammation, oxidative stress, apoptosis, and a-synuclein deposition. Cell proliferation will also restore insulin signaling to improve neuronal functions and provide...
1.The aim of this project is to establish a GLP-1 signaling pathway targeted cell model, for screening the new class of GLP-1 receptor agonists as anti-diabetic candidates.建立以GLP-1信号通路为靶点的药物筛选细胞模型,用于筛选GLP-1受体激动剂类的新型抗糖尿病药物。 2)GLP-1GLP-1受体 1.nGLP-...
[18] Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P.A., Drucker, D.J. 2003. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278:471-478. [19] Park, S., Dong, X., Fisher, T.L., Dunn, S., Omer, A.K., Weir, G., et al...
IL‑2signaling and the regulatory T‑cell pathway using computationally designed peptides).Invest.New Drugs,37,9‑16,2019。 [0629]28.A.Jazayeri等和F.H.Marshall.与肽激动剂结合的GLP‑1受体的晶体结构 (Crystal structure of the GLP‑1receptor bound to a peptide agonist).Nature, 546,254...