[31] Tao, Xin, et al. "Effects of metformin and Exenatide on insulin resistance and AMPKα-SIRT1 molecular pathway in PCOS rats." Journal of ovarian research 12.1 (2019): 1-8.[32] Bednarz, Krzysztof, et al. "The role of glp-1 receptor agonists in insulin resistance with concomitant ...
3.S. Song, R.Y. Guo, etal, Liraglutide attenuate central nervous inflammation and demyelination through AMPK and pyroptosis-related NLRP3 pathway, CNS Neurosci. Ther. 28 (3) (2022) 422–434. 免责声明
^Shigeto, M.; Ramracheya, R.; Tarasov, A.I.; et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J. Clin. Investig. 2015, 125, 4714–4728. ^[14]Shigeto, M.; Cha, C.Y.; Rorsman, P.; et al. A role of PLC/PKC-dependent pathway in GLP-...
[5]Laviola L, Leonardini A, Melchiorre M, et al. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. Endocrinology, 2012, 153 : 5770–5781. DOI:10.1210/...
[30] Drucker, D.J., Brubaker, P.L. 1989. Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci U S A 86:3953-3957. [31] Drucker, D.J., Campos, R., Reynolds, R., Stobie, K., Brubaker, P.L. 1991. The rat glucagon ...
Pathway/Library others Gene Summary This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-...
camp信号通路发挥生理功能,过程如下:glp-1通过和细胞膜表面的glp1r结合,激活胞内的信号,导致细胞内的腺苷酸环化酶活化和胞内camp浓度的上升,camp浓度的上升激活蛋白激酶a(cyclic-ampdependentproteinkinasea),磷酸化creb转录因子,磷酸化creb处于活化状态,进入细胞核激活胰岛素的转录翻译,最终分泌胰岛素(keggpathway:map...
(GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. ...
Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway[J]. Endocrinology, 2012, 153 :5770-5781. [49]Tibaduiza EC, Chen C, Beinborn M. A small molecule ...
Liraglutide has a therapeutic effect on obesity-related kidney disease, and such an effect may be achieved by inhibiting the CaMKKβ/AMPK signaling pathway in kidney tissue. 显示全部 2024-12-01·MOLECULAR AND CELLULAR ENDOCRINOLOGY Liraglutide prevents body and fat mass gain in ovariectomized Wistar...