Cytotoxic T cellsLymphocyte differentiationBiomedicinegeneralImmunologyA preprint by Daniel et al. reports a novel, late-stage phenotype of exhausted T cells that occurs concurrently with terminally differentiated exhausted T cells, determined by T cell receptor affinity for antigen....
T cell exhaustion limits effector T cell function in chronic infection and tumours1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, howev...
An Exhausted Phenotype of TH2‐Cells Is Primed by Allergen Exposure,But Not Reinforced by Allergen‐specific ImmunotherapyAITCTLA-4PD-1proallergic TH2T-cell exhaustionBackground Studies show that proallergic T(H)2 cells decrease after successful allergen-specific immunotherapy (AIT). It is likely ...
Recently, researchers have made progress in understanding exhausted T cells, with the definition and identification of exhausted T cells changing from phenotype-based to being classified at the transcriptional and epigenetic levels. Recent studies have revealed that e...
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood. Using newly generated recombinant antigen variant...
Therefore, future efforts are needed to improve the outcomes of these pts.A total of 18 pts with relapsed/refractory B cell malignancies, DLBCL (n=17) and ALL (n=1), were enrolled on a phase 1b/2 study (NCT02772198) of locally produced CD19 CAR T cells. Clinical response was ...
(Fc–IL-4), a typical type 2 cytokine, directly acts on CD8+T cells and enriches functional terminally exhausted CD8+T (CD8+TTE) cells in the tumour. Consequently, Fc–IL-4 enhances antitumour efficacy of type 1 immunity-centric adoptive T cell transfer or immune checkpoint blockade ...
Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127... The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearanc...
We addressed these important aspects in a cohort of 38 chronically HCV infected patients and found a coexpression of inhibitory receptors such as 2B4, CD160 and KLRG1 in association with PD-1 in about half of the HCV-specific CD8+ T cell responses. Importantly, this exhaustive phenotype was ...
T cells (Fig.2a) coinciding with higher glycolytic activity (Fig.2b). A similar metabolic phenotype was also observed in fully differentiated CTLs (Supplementary Fig.3h, i). Consistent with impaired mitochondrial respiration in mPiC-deficient T cells, we observed lower glucose-derived13C-labeling...