Gameiro SF, Ghasemi F, Barrett JW, Koropatnick J, Nichols AC, Mymryk JS, et al. Treatment-naive HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy. OncoImmunology. 2018;7(10):e1498439....
鈥塱mmune cells (p鈥?lt;鈥?.0001), and PD-L1鈥?鈥塱mmune cells (p鈥?lt;鈥?.0001). Endometrial cancers showing mismatch repair-deficiency and PD-L1 expression in tumor cells exhibit a prominent T cell-inflamed phenotype. More importantly, the increased number of FoxP3鈥?鈥塺egulatory ...
Although further studies are still needed to determine the identity of the four CD105− populations, these data suggest that apCAFs may be associated with a T cell-inflamed phenotype and is likely have important functions in regulating the Treg/CD8+ T cell ratio. Taken together, these studies...
In the immune-inflamed phenotype, immune cells infiltrate but their effects are inhibited. Notably, the three different phenotypes have different response rates to immune checkpoint inhibitors. 【4】Driving T cells into the TME is a gradual proces...
et al. Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma. Proc. Natl. Acad. Sci. USA 113, E7759–E7768 (2016). Article CAS PubMed PubMed Central Google Scholar Jerby-Arnon, L. et al. A cancer cell ...
(Fig.4c). We interrogated the functional link between FGFR3 signaling and the T-cell-depleted phenotype observed in UTUC. We reanalyzed a previously published dataset of mRNA expression from the RT-112 UC cell line following doxycycline (dox)-inducible short hairpin RNA (shRNA) knockdown of...
The increase in ECM cross-linking with aging places constraints on the mobility of immune cells, accounting for the phenotype associated with aging. Other situations often encountered in clinical practice may also lead to this phenotype (hereditary defects of cell mobility, and T cell depletion as ...
and CD26, a phenotype that is characteristic of bona fide DCs23. By contrast, recent single-cell transcriptomic studies of thymic leukocytes indicate that Flt3 is not expressed on macrophages, pDCs, or a recently identified monocyte-derived thymic DC population (Fig.4h, i and Supplementary Fig....
Incolitis, DC accumulate in the cLP, show an activated surface phenotype, up-regulate IL-12 p40 and p19 expression, and spontaneously stimulate NKT-like cells. cLP DC may be interesting targets for novel therapeutic approaches to modulate mucosal T cell responses in situ.doi:10.1002/eji....
Adult T cell leukemia (ATL) cells show a mature helper-inducer T cell phenotype and are thought to secrete many kinds of cytokines in vivo, complicating th... Y Yamada,Y Ohmoto,T Hata,... - 《Leukemia & Lymphoma》 被引量: 193发表: 1996年 T cell memory response to pneumococcal protein...