对于pan tumor(A左),黑色素瘤(A右),TMB 与 T cell–inflamed GEP signatures score相关性低,Spearman correlation coefficient r = 0.221, P < 0.05, and r = 0.252, P < 0.05, respectively ;HNSCC (中间)TMB 与 T cell–inflamed GEP signatures score相关性低 无相关性,(r = -0.020, P = 0.841) ...
Mutational Load and T-Cell-Inflamed Microenvironment May Predict Response to PembrolizumabSeiwert, TanguyJournal of Oncology Navigation & Survivorship
鈥塺egulatory T cells (p鈥?鈥?.0003), PD-1鈥?鈥塱mmune cells (p鈥?lt;鈥?.0001), and PD-L1鈥?鈥塱mmune cells (p鈥?lt;鈥?.0001). Endometrial cancers showing mismatch repair-deficiency and PD-L1 expression in tumor cells exhibit a prominent T cell-inflamed phenotype. More ...
To analyse the immune mechanisms of diffuse cutaneous systemic sclerosis (dcSSc) skin disease focusing on CD8+ T-cell responses in the affected skin of patients because chronic inflammation, vasculopathy, and extensive cutaneous fibrosis are prominent features of dcSSc skin disease, causing pain and ...
Identifying a strategy with strong efficacy against non-inflamed tumours is vital in cancer immune therapy. ERY974 is a humanized IgG4 bispecific T cell-redirecting antibody that recognizes glypican-3 and CD3. Here we examine the combination effect of ER
(2000). CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions. Eur. J. Im- munol. 30... G Bernard,V Raimondi,I Alberti,... - 《European Journal of Immunology》 被引量: 101发表: 2000年 The integrins An overview of a fami...
As T egress from inflamed sites is a potential control point of the , we aimed to determine alternative T exit receptors using a and a model. We show that + and - T exiting from the chronically inflamed skin were highly responsive to the ligand , which was induced in the lymphatics in...
Bialasiewicz, A.A., Schaudig, U., Ma, JX.et al.α/β- andγ/δ-T cell-receptor-positive lymphocytes in healthy and inflamed human conjunctiva.Graefe's Arch Clin Exp Ophthalmol234, 467–471 (1996). https://doi.org/10.1007/BF02539415 ...
EAE models have also contributed to the development of multiple disease-modifying treatments, all targeting primarily the immune system [13]. Using an EAE model it was found that T cell interaction with the inflamed BBB requires α4-integrins [14]. These findings were translated into the clinic...
F.115. Histamine Regulates Myelin-activated T Cell Function and Adhesiveness in Inflamed Brain MicrocirculationIn a previous work, we have estimated the left ventricular compliance invasively in animals by using data from both radionuclide ventriculography and intraventricular pressure obtained with a tip ...