TMB或T cell inflamed GEP与多个患者群组中(pan-tumor)的抗PD-1反应呈独立相关性。 (A和B)(A)TMB,定义为体细胞的非同义突变的总和(TMB was evaluated by whole-exome sequencing (WES) of germline and tumor DNA ),并与(B)T cell inflamed GEP组合进行了评估在pan tumor,头颈部鳞癌和黑色素瘤中 BOR(...
Mutational Load and T-Cell-Inflamed Microenvironment May Predict Response to PembrolizumabSeiwert, TanguyJournal of Oncology Navigation & Survivorship
In the process of driving T cells into tumors, there are many factors that can influence T-cell priming and T-cell homing to the tumor bed, leading to a noninflamed T-cell phenotype and failed antitumor immunity (Figure 3). Mechanisms o...
T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection. ...
4. Severe Human Lassa Fever Is Characterized by Nonspecific T-Cell Activation and Lymphocyte Homing to Inflamed Tissues Journal:Journal of Virology (4) Keywords:Lassa fever; Lassa virus, T cells, T-cell homing, host response, p...
鈥塱mmune cells (p鈥?lt;鈥?.0001), and PD-L1鈥?鈥塱mmune cells (p鈥?lt;鈥?.0001). Endometrial cancers showing mismatch repair-deficiency and PD-L1 expression in tumor cells exhibit a prominent T cell-inflamed phenotype. More importantly, the increased number of FoxP3鈥?鈥塺egulatory ...
promote the recruitment of CD8+T lymphocytes into tumor sites23,24,25, were significantly increased inArih1-WT-OE tumor lysates (Fig.3a, b), indicating that the activated STING pathway inArih1-WT-OE tumors might be responsible for the establishment of CD8+T cell “inflamed” microenvironment....
Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development....
‘Small cell lung cancers do not respond well to immune checkpoint blockade therapy, due to the poor recruitment of CD8 + T cells to the tumours. Here authors show that via combining radiotherapy, PARP inhibitors and anti-PD-L1 treatments, T cell infiltration and function could be improved...
[28] Bending D, Pesenacker A M, Ursu S, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis...