Endometrial cancers showing mismatch repair-deficiency and PD-L1 expression in tumor cells exhibit a prominent T cell-inflamed phenotype. More importantly, the increased number of FoxP3+regulatory T cells in mismatch repair-deficient endometrial cancers suggests that combination therapy by targeting both ...
We noted that the SCLC-Y subtype is characterized by enrichment in long-term survivors, high T-cell–inflamed GEP score, and HLA gene expression and low levels of CTA expression. This overall phenotype is consistent with a better differentiated tumor histology, an inflamed tumor microenvironment, ...
In the immune-inflamed phenotype, immune cells infiltrate but their effects are inhibited. Notably, the three different phenotypes have different response rates to immune checkpoint inhibitors. 【4】Driving T cells into the TME is a gradual proces...
Using a model wherein the T cell-inflamed tumor microenvironment is considered as a biological approximation of immunotherapy treatment response, we investigated molecular patterns that associate with the presence or absence of this phenotype with the idea that they may lead to therapeutic opportunities....
(Fig.4c). We interrogated the functional link between FGFR3 signaling and the T-cell-depleted phenotype observed in UTUC. We reanalyzed a previously published dataset of mRNA expression from the RT-112 UC cell line following doxycycline (dox)-inducible short hairpin RNA (shRNA) knockdown of...
The increase in ECM cross-linking with aging places constraints on the mobility of immune cells, accounting for the phenotype associated with aging. Other situations often encountered in clinical practice may also lead to this phenotype (hereditary defects of cell mobility, and T cell depletion as ...
Incolitis, DC accumulate in the cLP, show an activated surface phenotype, up-regulate IL-12 p40 and p19 expression, and spontaneously stimulate NKT-like cells. cLP DC may be interesting targets for novel therapeutic approaches to modulate mucosal T cell responses in situ.doi:10.1002/eji....
“cold”) phenotype of the tumor microenvironment is, however, hardly related to the availability of immunogenic (neo)antigens3. Instead, malignant cells often orchestrate a T cell-excluding microenvironment which confers resistance to immunotherapy4,5,6. Further, tumor-infiltrating T cells gradually ...
also be induced in Th3 cells for studies have shown that transient induction of TGF-β1 in T cells during activation in absence of IL-2 can drive generation of Foxp3+ Th3 cells which comprise a distinct Treg phenotype, which is CD25- and can control hyperproliferative T cell response[99]...
3 The mixed lymphocyte assay detects TCR activation while preserving T cell phenotype. a-c, We colonized germ-free mice with hCom1d, waited two weeks, and then sacrificed the mice. Immune cells from the colon were co-cultured for 4 h with three non-community bacterial strains (Bacillus ...