957 THE T-CELL EFFECTOR PHENOTYPE PROFILE IN AUTOIMMUNE SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF AUTOIMMUNE HEPATITISWe report the case of a patient with primary sclerosing cholangitis associated with systemic lupus erythematosus. Only one similar case has been previously reported. The relationship ...
T-cell vaccination in multiple sclerosis (2)Effectors: Theeffector cellsthat respond to stimulation with the target antigen(s) are activated CD4+cells of Th1 phenotype. Thevaccinationconsists of these autoreactive cells and produces tissue-damaging Th1 cytokines such as IFN-γ and TNF-α[18,19]...
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of interleukin-10 and expression of the inhibitory receptor PD-1. At homeostasis, blockade...
PD-L1 signaling also induced an anergic T-betIFN-纬phenotype in CD8T cells and was equally suppressive compared to PD-1 signaling; (2) PD-L1T cells restrained effector T cells via the canonical PD-L1鈥揚D-1 axis and were sufficient to accelerate tumorigenesis, even in the absence of ...
These T cell subsets were cultured in the presence of anti-CD3/CD28 antibodies and 1000 IU/mL IL-2 for 3 to 6 weeks. RAPA (1-100 nM) was added to half of the cultures. After harvest, the cell phenotype, signaling via the PI3K/mTOR and STAT pathways, expression of survival proteins ...
On the other hand, CD4+ T cells were also found to be responsible for the so-called cell-mediated immunity, or delayed-type hypersensitivity, which was characterized by the ability of these cells to induce inflammatory reactions mainly characterized by the activation of macrophages. The prototypic...
The critical role of human transcriptional repressor CTCF mRNA up-regulation in the induction of anti-HIV-1 responses in CD4 T cells 热度: Stiffness of Extracellular Matrix Components Modulates the Phenotype of Human Smooth Muscle Cells in Vitro and Allows for the Control of Properties of Engineered...
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediate... T Nakamura,RK Lee,SY Nam,... - 《Jou...
Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function GATA3在不同分子分型乳腺癌组织中表达的意义 三氧化二砷对MRL-lpr狼疮鼠T-bet-GATA3信号通路的影响 icos controls effector function but not trafficking receptor expression of kidney-infiltrating effector t cells in murine lu...
Circulating CD8+ T cells with a CD45RA+CD27- phenotype resemble cytolytic effector cells because they express various cytolytic mediators and are able to execute cytotoxicity without prior stimulation in vitro. We here demonstrate that CD8+CD45RA+CD27- T cells can use both granule exocytosis and...