In three independent T1D cohorts, we find that low frequency of circulating Tcells is associated with reduced beta-cell function and with the presence of diabetic ketoacidosis. Since autoreactive CD8T cells mediate disruption of insulin-producing beta cells, we demonstrate that Tcells can suppress ...
However, it is unclear whether human cytotoxic CD8T cell (CTL) responses also rely on an intrinsic complement-inflammasome axis. Here we show, using CTLs from patients with CD46 deficiency or with constitutively-active NLRP3, that CD46 delivers co-stimulatory signals for optimal CTL activity by...
B. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22, 817–890 (2004). Article CAS PubMed Google Scholar Devilder, M.-C. et al. Potentiation of antigen-stimulated Vγ9Vδ2 T cell cytokine production by immature dendritic cells (DC) and reciprocal effect on DC ...
During T cell development, hematopoietic stem cell-derived NK/T precursors generate thymocytes that mature in the thymus through double negative (DN), double positive (DP) and single positive (SP) phases defined by CD4/CD8 coreceptor expression. Pre-TCR and TCRαβ expression constitute checkpoint...
Fingolimod (FTY720), the first oral treatment for multiple sclerosis (MS), blocks immune cell trafficking and prevents disease relapses by downregulation of sphingosine-1-phosphate receptor. We determined the effect of FTY720 on human T cell activation and effector function. T cells from MS patients...
miR-232724 clusters control effector T cell differentiation and function The miR-23∼27∼24 clusters control differentiation of effector T cells. In particular, miR-24 targets IL-4 and miR-27 targets GATA3, thus collaborating in the control of Th2 immunity. Coordinated repression of gene ...
Critically, RelB within APCs was required for the expansion of donor helper T cell type 1 (Th1) effectors and subsequent alloreactivity, but not the peripheral expansion or function of donor FoxP3+ regulatory T cells. These data suggest that the targeted inhibition of nuclear RelB translocation...
Effector function of T in has been widely studied with mixed populations of lymphoid T stimulated ex vivo, but this approach does not permit evaluation of the contribution by a single T clone in the inflammatory site during . We have investigated both in vitro and in vivo in a panel of dia...
LAG-3 regulates [CD8.sup+] T cell accumulation and effector function in murine self- and tumor-tolerance systems.(Research article)(Report) JF Grosso,CC Kelleher,TJ Harris,... 被引量: 0发表: 0年 Kinetics of Virus-Specific CD8[sup +]-T-Cell Expansion and Trafficking following Central ...