In three independent T1D cohorts, we find that low frequency of circulating Tcells is associated with reduced beta-cell function and with the presence of diabetic ketoacidosis. Since autoreactive CD8T cells mediate disruption of insulin-producing beta cells, we demonstrate that Tcells can suppress ...
However, it is unclear whether human cytotoxic CD8T cell (CTL) responses also rely on an intrinsic complement-inflammasome axis. Here we show, using CTLs from patients with CD46 deficiency or with constitutively-active NLRP3, that CD46 delivers co-stimulatory signals for optimal CTL activity by...
During T cell development, hematopoietic stem cell-derived NK/T precursors generate thymocytes that mature in the thymus through double negative (DN), double positive (DP) and single positive (SP) phases defined by CD4/CD8 coreceptor expression. Pre-TCR and TCRαβ expression constitute checkpoint...
B. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22, 817–890 (2004). Article CAS PubMed Google Scholar Devilder, M.-C. et al. Potentiation of antigen-stimulated Vγ9Vδ2 T cell cytokine production by immature dendritic cells (DC) and reciprocal effect on DC ...
miR-232724 clusters control effector T cell differentiation and function The miR-23∼27∼24 clusters control differentiation of effector T cells. In particular, miR-24 targets IL-4 and miR-27 targets GATA3, thus collaborating in the control of Th2 immunity. Coordinated repression of gene ...
Whether and, if so, how Mg2+ availability in tissues is sensed and integrated functionally by CD8+ T cells has not been investigated. Results First, we explored how Mg2+ affected memory CD8+ T cell function in vitro, using complete media containing 1.2 mM Mg2+ versus no Mg2+ as the only...
CC Chemokine Ligand 3 (CCL3) Regulates CD8+-T-Cell Effector Function and Migration following Viral Infection CC Chemokine Ligand 3 (CCL3) Regulates CD8 + -T-Cell Effector Function and Migration following Viral Infection. J Virol. 2003;77:4004-14. doi:10.1128... MJ Trifilo,CC Bergmann,WA ...
cell function, regulating a substantial amount of unique target genes in each cell type. We also show that, differently from the severe inflammatory phenotype observed in mice with T cell-specific (CD4creor LCKcre-mediated) deletion of Blimp, Foxp3+Treg cell-specific deletion of Blimp1 leads ...
Themis is a T cell lineage-specific molecule that is involved in TCR signal transduction. The effects of germline Themis deletion on peripheral CD4+ T cell function have not been described before. In this study, we found that Themis-deficient CD4+ T cell