Jing FangBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, ChinaWenbin ZhangBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China...
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. Follicular helper T cell in immunity and autoimmunity Effector cells. VSV-N peptide-specific CTLs were maintained in vitro by weekly stimulatio...
The first stage, the 'expansion' phase, is initiated in the lymphoid tissues, where encounter with antigen induces naive T cells to clonally expand and dif- ferentiate into effector T cells — known as T helper (TH) cells or cytotoxic T lymphocytes (CTLs) for CD4+ and 252 | APRIL 2002...
While the role of activated CD4+ helper T cell subpopulation has been established in SLE, additional rare T cell subpopulations have more recently moved into the focus of research. Recent studies provide evidence that TCR+ CD3+ CD4− CD8−, so-called “double negative” (DN) T cells, ...
T lymphocytes are key players in the regulation and promotion of adaptive immunity. Helper T cells (TH), cytotoxic T lymphocytes (CTL), and regulatory T cells (Treg) shape cellular networks through the assembly of cell-cell interfaces termed Immunological Synapses (IS) with antigen-presenting cel...
demonstrated a crosstalk between PD-1 and CD134 (OX40) regarding T-helper-cell differentiation and anti-plasmodium humoral immunity in humans [8]. The CD134/OX40L axis is pivotal for the CD4+ differentiation toward effector T-cells. On the other hand, T-cell activation can be dampened by...
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4 Central Memory T Cells We previously reported that central–memory T cells (TCM cells), which express lymph node homing receptors CCR7 and CD62L, are largely devoid of effector f.....
Acquired immunodeficiency syndrome is associated with a viral (HTLV-III/LAV)-mediated progressive depletion of a helper/inducer T4+ T cell subset, whereas acute T cell leukemia is associated with a viral (HTLV-I)-mediated growth of the same T cell subset. Because large granular lymphocytes (LGL...
d–f ChIP-PCR assay was performed to analyze the binding of XBP1s to Trap1 promoter in 293 T cells. d Three sets of primer pairs covered the − 296 ~ − 451, − 559 ~ 694, − 749 ~ 903 regions, and qPCR showed that XBP1s bound to − 296 ~ − 451...
and myeloid cells1. Blimp1 was initially thought to function only as a repressor of gene expression. More recent studies3,4however, indicate that Blimp1 can also function as an activator of gene expression. In T cells, Blimp1 regulates differentiation of follicular helper T cells5, IL10 expre...