T‐cell–inflamed GEP score was defined as non‐low or low using a cutoff of ?1.54. A combined positive score (CPS) ≥10 was defined as PD‐L1 expression positivity. Associations between overall survival (OS) an
TMB 与T cell–inflamed Gene expression profile 将肿瘤分成新的“四型”:A,TMB low,低免疫原性,TME中存在T细胞inflammed; B,尽管TMB high,且免疫原性高,肿瘤仍然逃逸免疫编辑;C,尽管有T细胞浸润,但是功能受到TME中的基质细胞,内皮细胞因子的影响,TMB 低, 低免疫原性;D,TMB high,高免疫原性,T cell inflammed...
While a T cell inflamed gene expression profile (GEP) has predicted anti-PD-1 response in various cancers, it failed in a large NSCLC cohort from the Stand Up To Cancer-Mark (SU2C-MARK) Foundation. Re-analysis revealed that while the T cell inflamed GEP alone was not predictive, its ...
The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor mutational burden (TMB) may also dictate response, and some oncogenes (i.e., WNT/β-catenin) are known to mediate immunosuppression...
c Gene expression signatures associated with TR TIL products. GEP score was calculated by averaging the expression level of the genes included in the IFN-γ signature, Expanded immune signature and T-cell inflamed signature. d GEP score was plotted against the TMB value in each patient. *P ...
The SCLC-Y subtype was associated with high expression of interferon-γ response genes, highest weighted score on a validated 18-gene T-cell–inflamed gene expression profile score, and high expression of HLA and T-cell receptor genes. YAP1 protein expression was more prevalent and more ...
significance in the Figure 2A meta-analysis (final column [11 total]), validation cohort results), namely clonal TMB, indel TMB, NMD-escape TMB, tobacco signature, UV signature, APOBEC signature, sex, T cell inflamed GEP signature, and gene expression values for CD274 (PD-L1), CD8A, and ...
Results CX3CR1 previously expression reported a on memory CD8 þ T cells. We unique murine memory CD8 þ have T-cell population with proliferative potential that is distinct from TCM and is induced by non-professional antigen-presenting cells in the liver but not lymphoid tissues12. We ...
Background To develop a contrast-enhanced ultrasound (CEUS) radiomics- based machine learning model for predicting T cell-inflamed gene expression profile (GEP) in hepatocellular carcinoma (HCC) patients. Methods A primary cohort of 268 HCC patients with preoperative CEUS was enrolled and RNA ...
Ott PA, Bang Y, Razak ARA, Bennouna J, Soria J, Rugo HS, et al. Relation- ship of PD-L1 and a T-cell inflamed gene expression profile (GEP) to clinical response in a multicohort trial of solid tumors (KEYNOTE [KN028]). Ann Oncol. 2017;2(suppl_5):v22-42....