Cell type–specific genetic regulation of gene expression across human tissues GTEx项目已经确定了人体组织中大部分基因的顺式数量性状基因座(QTL)表达和剪接定量性状基因座。该研究绘制了细胞类型丰度和基因型的计算估计之间的相互作用,以确定七种细胞类型的细胞类型-相互作用QTL,并表明细胞类型相互作用表达QTL比组织...
Cell type–specific genetic regulation of gene expression across human tissues GTEx项目已经确定了人体组织中大部分基因的顺式数量性状基因座(QTL)表达和剪接定量性状基因座。该研究绘制了细胞类型丰度和基因型的计算估计之间的相互作用,以确定七种细胞类型的细胞类型-相互作用QTL,并表明细胞类型相互作用表达QTL比组织...
转录是遗传信息从DNA到RNA传递的关键步骤,也是RNA生物合成的最主要形式。转录是在启动子和特定的转录因子(transcription factors, TFs)以及其他调控蛋白的相互作用下发生的,发生的位点位于基因旁侧序列中,被称为顺式调控元件(cis-regulatory elements, CREs),一般包括启动子、增强子、调控序列和可诱导元件等【1】。致密...
Cell type–specific genetic regulation of gene expression across human tissues GTEx项目已经确定了人体组织中大部分基因的顺式数量性状基因座(QTL)表达和剪接定量性状基因座。该研究绘制了细胞类型丰度和基因型的计算估计之间的相互作用,以确定七种细胞类型的细胞类型-相互作用QTL,并表明细胞类型相互作用表达QTL比组织...
Biomedical engineering Cell type specific gene expression| Profiling and targeting UNIVERSITY OF CALIFORNIASAN DIEGO Lanping A. SungEdward M. Callaway NathansonJason LawrenceThe mammalian central nervous system is a complex network of functionally and anatomically intertwined cell-types. The roles of ...
Cell-type-specific analysis of alternative polyadenylation using single-cell transcriptomics data Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina Cell type–specific genetic regulation of gene expression across human tissues
The cell clusters showed distinct gene expression patterns represented by cell type-specific marker genes。 第一步这里构建伪SPOTA specific number of cells (k = 8) were randomly sampled from the single-cell data with random weights to generate pseudospots(number of pseudospots = 20000),(8个细胞...
(TRAP) to detect changes in gene expression in specific cell types resulting from heat shock in zebrafish9. However, this method has not, to our knowledge, been used to detect cell type-specific differential gene expression in response to wounding. Using this method, we identified several ...
Wang, Y. J., Kaestner, K. H.Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled?.Cell Metabolism.29(3), 539-544 (2019). Explore More Videos Keywords TRAP seq Cell Type specific Gene Expression Liver Hepatocytes ...
SCADIE: simultaneous estimation of cell type proportions and cell type-specific gene expressions using SCAD-based iterative estimating procedure Nucleic Acids Res 16.971 SCAPE: a mixture model revealing single-cell polyadenylation diversity and cellular dynamics during cell differentiation and reprogramming ...