Cell type–specific genetic regulation of gene expression across human tissues GTEx项目已经确定了人体组织中大部分基因的顺式数量性状基因座(QTL)表达和剪接定量性状基因座。该研究绘制了细胞类型丰度和基因型的计算估计之间的相互作用,以确定七种细胞类型的细胞类型-相互作用QTL,并表明细胞类型相互作用表达QTL比组织...
而这篇Cell文章的突出贡献是,巧妙利用了小鼠初级视皮层的后天经历易操控性,揭示了视皮层2/3层连续变化的神经细胞类型是由后天经历调控细胞类型标记基因 (cell-type specific marker genes) 的梯度表达来决定的。有趣的是,在其他脑区,比如海马和杏仁核,也存在连续变化的细胞类型【8-10】。因此,这篇文章提示了后天经...
题目:组织特异性遗传特征为临床试验中药物副作用的预测提供依据 Tissue-specific genetic features inform prediction of drug side effects in clinical trials 通过结合48个组织中的基因表达和eQTL,该研究评估了> 360000个英国生物库个体中1167个表型的全表型关联研究(PheWAS),以分析是否可在临床试验中预测药物副作用。...
A majority of cells in subclones A/B expressed signature genes associated with progenitor-like cells . In contrast, nearly all subclone C cells expressed genes associated with differentiated monocyte-like or cDC-like cells.这些结果表明,替代的FLT3基因型可以深刻影响单个肿瘤内AML亚克隆的细胞层次. 基因...
specific and cell type-specific DEGs across human and mouse stromal cell types at 6–7 weeks and E11.5 (P value < 0.01, Wilcoxon rank-sum test). These DEG sets included ‘Common markers for stromal cells’, ‘Shared DEGs’, ‘Human SC_BDNF+ specific’, ‘Mouse mesothelium-specific’ ...
2. 然后就是鉴定eQTL(ci)在不同肾脏细胞类型中的共享性,用的方法是multivariate adaptive shrinkage method (mash)。定义只在一种细胞中LFSR<0.05的作为cell type-specific eQTL(ci)。最后约有18%的eQTL(ci)是细胞特异性的 举了个栗子,rs783153-LPA的eQTL(ci)效应是以PT细胞中为主导的 ...
We further validated novel marker genes using an orthogonal ATAC-seq dataset. We performed multiscale coexpression network analysis of the single cell data sets and identified robust cell-specific gene modules. To facilitate the use of the cell type-specific genes for cell type proportion estimation...
To investigate the molecular mechanisms underlying the development and the biological functions of glial cells, glial cell-specific genetic manipulation is crucial. Currently, transgenic mice and knockin mice using cell type-specific genes have been widely used to manipulate gene expression in astrocytes ...
(OR) genes from different chromosomes converge in a small number of heterochromatic foci. These foci are OR exclusive and form in a cell-type-specific and differentiation-dependent manner. The aggregation of OR genes is developmentally synchronous with the downregulation of lamin b receptor (LBR) ...
Differential gene expression patterns in cells of the mammalian brain result in the morphological, connectional, and functional diversity of cells. A wide variety of studies have shown that certain genes are expressed only in specific cell-types. Analysi