EP0453242A1 1991年4月16日 1991年10月23日 The General Hospital Corporation Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication... Breakfield,Xandra O.,RL Martuza - EP 被引量: 311发表: 1991...
gene expression in T cellsdoi:10.1067/mai.2002.121145Our results demonstrate that the acetylation state of histones associated with the IL-4 promoter is a key regulator ofMasao TodaMeri K. TulicRoy C. LevittQutayba HamidRetour Au Numéro
因为前面介绍的都是斑马鱼中的crisper cas9谱系示踪方法,这里再来打卡一篇在小鼠中应用crisper cas9技术的文章,题目是An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells。知乎的标题因为有字数的要求,我这里做了修改,希望不要引起歧义。
gene expression 英[dʒi:n iksˈpreʃən] 美[dʒin ɪkˈsprɛʃən] 释义 基因表达[表现] 实用场景例句 全部 That cell hybridization can be used to dissect regulatory mechanisms controllinggene expressionin eukaryotic cells....
Gene expression profiling, the simultaneous measurement of the global patterns of gene expression in cells using microarray technologies, has held promise to improve diagnosis, risk classification, and outcome prediction in acute leukemias as well as in other human cancers. But how much has gene expre...
Gene therapy involves the introduction of new genes into cells, to restore or add gene expression, for the purpose of treating disease. Most commonly a mutated gene is replaced with DNA encoding a functional copy. Alternatively DNA encoding a therapeutic protein drug may be introduced. ...
Number and types of RNAs and proteins in different tissues have been found to be different even though each cell of the organism has identical copies of DNA suggesting thereby that these differences are due to differential expression of genes in these cells. The manner in which a cell responds...
was introduced into HeLa cells, followed by cell culture for a period of 36 h to allow for the expression of the construct. As an RNA-binding protein, FUS is known to display liquid–liquid phase separation in the nucleus. When exposing transfected HeLa cells to hyperosmotic stress by the...
Gene Expression Profiling of Dendritic Cells by Microarray The immune system of vertebrate animals has evolved to respond to different types of perturbations (invading pathogens, stress signals), limiting self-tiss... M Foti,P Ricciardi-Castagnoli,F Granucci - 《Methods in Molecular Biology》 被引量...
To understand the gene regulatory system that governs the self-renewal and pluripotency of embryonic stem cells (ESCs) is an important step for promoting regenerative medicine. In it, the role of several core transcription factors (TFs), such as Oct4, Sox2 and Nanog, has been intensively invest...