Similarly, the ability of monocytoid cells to adhere to endothelial cells, and the ability of monocytoid cells to undergo chemotaxis, chemokinesis, or phagocytosis has been found to be dependent upon Mac-1 (Keizer, G. D., et al., Eur. J. Immunol. 17:1317-1322 (1987)). Any of the ...
Deletion of the COOH-terminal domain of A-Myb, or co-expression with Ets-2 resulted in increased transactivation potential. While ectopic overexpression of c-myb in 32Dcl3 cells results in a block to the ability of these cells to undergo terminal differentiation resulting in indefinite growth in...
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Cannabinoid receptors exhibit marginal expression in the normal liver but undergo enhanced expression in the fibrotic human liver, predominately in activated hepatic stellate cells (HSCs)2. A critical aspect in chronic liver disease is the activation of resident HSCs into proliferative, contractile, and...
Migration and invasion assays verified that the downregulation of PNO1 expression suppressed the migration and invasion abilities of A549 and NCI-H1299 cells, respectively (Fig. 2c–f). The wound-healing assay (Fig. 2g, h) also confirmed that PNO1 promoted the ability of nondirectional ...
perniciosa undergo distinct metabolic changes as they transition from the biotrophic phase to the necrotrophic phase of growth [15–19]. These metabolic changes suggest significant shifts in gene expression and in enzymatic processes. In this study we present the genome of M. roreri and compare it...
Cells undergo DNA repair and maintain genome integrity and stable promote cell survival. Similar to the ATR, ATM controls the phosphorylation of p53, BRCA1, and CHK2, which play a crucial role in the ATM-CHK2 pathway [29–31]. CHK1 and CDK1 are hub genes in the ATR-CHK1 pathway. ...
21. The composition of the tubal fluid is also modulated by hormonal changes initiating the synthesis of mucopolysaccharides and enzymes in the tubal secretory cells during ovulation22. In pigs, sperm binding may induce sex-specific changes in gene expression of oviductal cells in vivo with 501 ...
The mechanism by which buffalo parasites undergo “transformation” during passage in cattle is unknown. In recent years, epigenetic mechanisms of regulating gene expression that affect cellular phenotypes have received increasing attention (Lowdon et al., 2016). Studies of Plasmodium parasites have impli...
In a second step after the initial insult, expression of different isoforms of the cell membrane protein Flower (Fwe) label cells as winners or losers (Rhiner et al., 2010). Interestingly, this gene has been recently implicated in the susceptibility to skin papilloma in mice (Petrova et al....