CD8T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent T cell receptor stimulation in the tumor microenvironment (TME). Exhausted T (T) cells are characterized by upregulation of coinhibitory molecules and ...
T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes directly to tumor cell killing owing to its cytotoxic effector function. However
Having established that impaired mitochondrial ATP production coincides with the transition of Tpex into Tex cells, we set out to delineate if these metabolic changes are a consequence or the cause of T cell exhaustion. To directly address the role of mitochondrial bioenergetics, we generated mice ...
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control TEX differentiation remains unclear. We showed that TEX cells shifted from...
(d), cell proportion in each cluster (e) and systematic expression comparison of carbohydrate metabolisms among top four clusters (f).g,h, T cell counts (g) and frequencies of granzyme B+IFNγ+(h) among ex vivo-induced CD8+TTEcells with or without 2-DG (n = 4 biological ...
Methods T cell populations were isolated from murine melanoma–B16-F10 or a lab-generated melanoma clone of the spontaneous BREF/PTEN model–by expression of inhibitory receptors and assayed in tandem in microsuppression assays. Murine melanoma clones with inhibited oxidative metabolism were generated ...
Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver, and tumor tissues from 46 HCC patients, we detected 91 different antigen-specific CD8+ T cell populations targeting HBV, neoantigen, tumor-associated, and disease-unrelated antigens. Parallel high-dimensional...
However, the article also acknowledges the need for further research to validate these approaches and address potential limitations and side effects. 展开 关键词: CAR (chimeric antigen receptor) NK cell cholesterol metabolism tumor microenvironment DOI: 10.3389/fphar.2024.1440869 年份: 2024 ...
tTex cell suppression requires CD39, which generates immunosuppressive adenosine. Restricted deletion of CD39 in endogenous CD8+ T cells resulted in slowed tumor progression, improved immunotherapy responsiveness and enhanced infiltration of transferred tumor-specific T cells. CD39 is induced on tTex ...
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