Epigenetics describes a phenomenon of modifications in gene expression caused by heritable, but potentially reversible, alterations in the chromatin structure, DNA methylation, and post-transcriptional effects of small noncoding (micro) RNAs (miRNAs), without changes in the DNA sequence. These mechanisms...
It is challenging to define how promoter hypermethylation participates in gene silencing and how the loss of methylation alters chromosome structure. Nevertheless, the findings of DNA methylation abnormalities in cancer have a potential clinical impact. One of the potential targets appears to lie in ...
Epigenetics (Lifestyle) is a new field of biology that is exploring the effect of the environment on cellular behavior. The "environment" includes one's physical, social, and electromagnetic environment as well as beliefs, perceptions, lifestyle, habits, behaviors, and mind-body practices such ...
Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life,...
A panel of epigenetic biomarkers is preferred to a single biomarker in clinical assays. Changes in gene expression due to epigenetic regulation can be reversed by chemicals, and this approach opens up a novel approach in cancer prevention and treatment....
Epigenetics of Cancer Prevention, Volume Tenis the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, to...
and one of utmost importance to the translational impact for cancer prevention, diagnosis, and treatment, concerns delineation of the molecular underpinnings of how the cancer epigenome evolves.32This investigation has benefited from, and contributed to, the explosion of knowledge over the past 5 to ...
Cancer Treat Res 1995;72:91-110.Verma M, Srivastava S: Epigenetics in cancer: implications for early detection and prevention. Lancet Oncol 2002, 3(12... S Srivastava,BS Kramer - Springer US 被引量: 311发表: 1994年 Introduction: epigenetics and cancer. implication for better understanding of...
Dunn B K,Verma M,Umar A.Epigenetics in cancer prevention:early detection and risk assessment: introduction.Annals of the New York Academy of Sciences. ... BK Dunn,M Verma,A Umar - 《Ann N Y Acad Sci》 被引量: 115发表: 2010年 Introduction: Epigenetics and Cancer The field of epigenetic...
cancer patients. Here, we provide an overview of clinical epigenetics within the context of network analysis. We illustrate achievements to date and discuss how we can move from traditional medicine into the era of network medicine (NM), where pathway-informed molecular diagnostics will allow ...