In this chapter, we focus on the role of epigenetics in normal and pathological cell development. We outline recent large-scale assays of epigenetic profiling in normal and cancer tissue samples as well as pertinent new discoveries linking epigenetics and cancer....
Thyroid cancer (TC) represents one of the most prevalent endocrine malignancies, with a rising incidence worldwide. Epigenetic alterations, which modify gene expression without altering the underlying DNA sequence, have garnered significant attention in recent years. Increasing evidence underscores the pivo...
The past decade has seen the emergence of immunotherapy as a prime approach to cancer treatment, revolutionizing the management of many types of cancer. Despite the promise of immunotherapy, most patients do not have a response or become resistant to tre
role of epigenetics in age-related macular degeneration M Gemenetzi1 and AJ Lotery1,2 Abstract It is becoming increasingly evident that epigenetic mechanisms influence gene expression and can explain how interactions between genetics and the environment result in particular phenotypes during development. ...
The deregulation of epigenetics in cancer is common and results in both the activation of oncogenes and the silencing of tumor suppressors. A tremendous amount of research corroborates the existence in many tumor types of a cancer stem cell that is both the origin and cell type responsible for...
Peter LichterJohn Wiley & Sons, LtdInternational Journal of CancerLichter P (2008) The role of epigenetics in carcinogenesis. International Journal of Cancer 123: ix.Lichter, P., 2008. The role of epigenetics in carcinogenesis. Int J Cancer 123, ix....
Expression of CDK1 has also been found to be increased in bladder cancer cells, parallel with over-expression of the long non-coding RNA (lncRNA) PVT1. Notably, suppression of PVT1 has decreased activity, proliferative potential, colony formation, migratory capacity, and invasiveness of bladder ...
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gra
This theory model is known as the Developmental Origins of Health and Disease (DOHaD) theory, in which postulates that "epigenetic memories", involving ... K Mochizuki,C Imai,N Sato,... 被引量: 0发表: 2017年 Epigenetic Epidemiology || The Role of Epigenetics in the Developmental Origins of...
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures, resulting in the release of cellular contents that can activate strong inflammatory and immune responses. P