deletions, and truncations, recent research has revealed their diverse roles in biological processes, including disease pathogenesis.Although many HERVs remain inactive, they have been implicated in various diseases, particularly cancer, prompting an increased interest in harnessing HERVs for therapeutic pu...
Historically, research has focused on the genetic basis of cancer, particularly mutational activation of oncogenes or inactivation of tumor-suppressor genes (TSGs). Since Nowell proposed the clonal evolution of tumor cell populations in 1976, tumor heterogeneity, especially ITH, was actively studied [...
This cell cycle machinery is often deregulated in cancer as a consequence of the silencing of various tumor suppressor genes (Collins et al., 1997, Tallen and Riabowol, 2014). In fact, loss of tumor suppressor genes and their encoded proteins through deletion, inactivating mutations, epigenetic...
the very title of which “Does cancer kill the individual and save the species?” conveys in the implicit form its basic ideas: (1) cancer carries out a certain function and
Gene expression patterns change during the initiation, progression, and development of cancer, as a result of both genetic and epigenetic mechanisms. Genetic changes arise due to irreversible changes in the nucleotide sequence, whereas epigenetic changes occur due to changes in chromatin conformation, hi...
V. Epstein–Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate. Transpl. Infect. Dis. 3, 177–185 (2001). CAS PubMed Google Scholar Archin, N. M. et al. Administration of vorinostat ...
altered before the lesions became malignant, suggesting that they could be a key event in tumour evolution. The cause of global hypomethylation in cancer is unknown but the outcome, in due course, may be that oncogene expression is increased or other genes important for growth control are ...
We found that tumorigenic transformation of hMSC-TERT20 cells induced the expression of members of several cancer-germline antigen gene families (ie, GAGE, MAGE-A, and XAGE-1), with promoter hypomethylation and histone acetylation of the corresponding genes. Both in vitro cultures and tumor ...
Because some epigenetic changes can be reversed chemically, epigenetics has tremendous implications for disease intervention and treatment.After epigenetic components in cancer were characterized, genes and pathways are being characterized in other diseases such as diabetes, obesity, and neurological disorders...
Gure AO, Chua R, Williamson B, Gonen M, Ferrera CA, Gnjatic S et al (2005) Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. Clin Cancer Res 11:8055–8062 CASPubMedGoogle Scholar ...