The goal of this work was to develop methods that would leverage the throughput of second-generation DNA sequencing technologies to identify genetic and epigenetic mutations in cancer. The first method, Nested Patch PCR, was designed to provide a cost-effective way to identify genetic mutations in...
The past decade of discovery in cancer epigenetics has revealed a number of similarities between cancer genes and stem cell reprogramming genes, widespread mutations in epigenetic regulators, and the part played by chromatin structure in cellular plasticity in both development and cancer. In the light...
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adop
MLL3 and MLL4 are both found to be highly mutated in cancer [4,10,18,78]. MLL3 has a mutation hot spot at the plant homeodomain (PHD) cluster, whereas MLL4 mutations are more evenly distributed throughout the protein [10,18]. Our recent study documented that mutations within the MLL3 ...
Marked for death: targeting epigenetic changes in cancer In the past few years, it has become clear that mutations in epigenetic regulatory genes are common in human cancers. Therapeutic strategies are now being developed to target cancers with mutations in these genes using specific chemical ... ...
The pathogenic role for heritable mutations in the DNA sequence of tumor suppressor and DNA repair genes has been well established in familial cancer syndromes. These germ line mutations confer a high risk of developing particular types of cancer, according to the gene affected, at a young age ...
And just like the hard drive can go wrong, in the form of DNA mutations, even more so probably, epigenetics can be abnormally regulated in cancer cells, which tells genes to be overactive when they should not be. Or, as we often study, the dysregulation is in the form of genes losing...
Genetic mutationsPhytochemicalsTherapeutic approachesLung cancer, a leading cause of cancer-related deaths worldwide, is primarily linked to smoking, tobacco use, air pollution, and exposure to hazardous chemicals. Genetic alterations, particularly in oncogenes like RAS, EGFR, MYC, BRAF, HER, and ...
DNA methylation in cancer and aging. Cancer Res. 76, 3446–3450 (2016). Article CAS Google Scholar Shih, A. H., Abdel-Wahab, O., Patel, J. P. & Levine, R. L. The role of mutations in epigenetic regulators in myeloid malignancies. Nat. Rev. Cancer 12, 599–612 (2012). ...
Since changes in repeats are frequent and reversible, repeats provide a unique type of mutation that bridges the gap between rare genetic mutations, such ... A Jansen,R Gemayel,KJ Verstrepen - 《Genome Dyn》 被引量: 46发表: 2012年 Epigenetic drift, epigenetic clocks and cancer risk It is...