The aim of this review work is to explain the current progression in the alterations of epigenetics in cancer and the changes in cancer initiation,progression and the potential use of this knowledge in designing most effectivePrakash Agilan N....
[Epigenetic modifications in cancer]. Abnormal function of genes and modified gene expression patterns play a major role in cancer. Scientists have been investigating origins of human cancer for decades and debating the relative roles of genetic and epigenetic abnormalities ... A Tieva,P Peltom...
Ferroptosis, a novel form of iron-dependent lipid peroxidation mediated regulated cell death (RCD) in cellular membranes, has recently been shown to functions as a dynamic tumor suppressor in cancer development, highlighting regulating ferroptosis can be utilized as an interventional target for tumor tr...
several mutations on histone tails (H3K27M, H3K36M and H3G34V/R) have been found to be associated with tumorigenesis in different types of cancers [120]. A common feature of the mutated “oncohistones” is that they all impede the deposition of the proper histone modification at the mut...
In conclusion, epigenetic regulation plays a critical role in the development and progression of cancer. Aberrant DNA methylation, histone modification, and non-coding RNA expression can lead to dysregulation of gene expression, ultimately contributing to the development of cancer. The reversibility of ...
1). First, we briefly introduce the changes in glucose, lipid, and amino acid metabolism in cancer cells. Then, we discussed the regulatory effects of DNA methylation, histone modification, chromatin remodeling, and noncoding RNA on metabolic reprogramming in tumor cells. Finally, we discuss the...
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adop
Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic modifications, control wh
Finally, we will speculate on the benefit of PcG inhibition for cancer treatment, reviewing potential pharmacological strategies. 展开 关键词: cancer chromatin modification epigenetics histone modification Polycomb transcription DOI: 10.2217/fon.10.157 被引量: 102 ...
modification (PTM) of amino acids in the N-terminus of histones, including histone acetylation, histone methylation, and histone ubiquitination [13]. Histone modification affects the development and prognosis of lung cancer [14], glioma [15], breast cancer [16], peripheral T-cell lymphoma [17]...