Epigenetic Therapy for Cancer Stem CellsCANCER stem cellsSTEM cell treatmentEPIGENETICSCANCER relapseCYTOLOGYEPIGENOMICSSubstantial evidence has shown that tumors can emerge from a distinct, small population of cells known as cancer stem cells (CSCs), which have a vital role in the initiation, ...
(AR). A member of a family of proteins called nuclear receptors which bind lipophilic steroid molecules. AR interacts with androgens, binds to androgen receptor element (ARE), and causes transcription activation of its target genes; it is a common target of therapy for prostate cancer. ...
DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer DNA methylation is an epigenetic modification involved in gene expression regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an a... S Varinder,S Prince,C Neena - 《Current Cancer Drug Targets》 被引量: ...
CancerDeacetylationDNA methylationDNA methyltransferasesEpigenetic drugsHistone deacetylasesdoi:10.1016/B978-0-12-799958-6.00018-4Bowen YanXuehui LiAlta JohnsonYurong YangWei JianYi QiuElsevier Inc.Yan B, Li X, Johnson A, Yang Y, Jian W, Qui Y. Epigenetic drugs for cancer therapy. In: Huang S,...
October 14, 2009 Share Share Pin 0Share Researchers studying cancer epigenetics therapies dream of days when we might be able to control DNA methylation like our car stereos…less treble, little more bass. 5 Aza is one of the early leaders in the epi pipeline, and like a lot of therapeutic...
Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev 1995; 9: 1211-22.]. Several genes sharing similar biological features have since been discovered, and are currently grouped into the JMJ......
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adop
Cancer stem cells (CSCs) are rare tumor cells that exhibit stem cell properties such as self-renewal capacity and pluripotency. In recent years, cancer ste... B Kaminska,DW Kulesza,K Ramji - 《Current Signal Transduction Therapy》 被引量: 6发表: 2013年 Targeting of epigenetic regulators in ...
"We think this is a central dogma for future therapy," Shilatifard said. More information:Lu Wang et al. Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy,Nature Medicine(2018).DOI: 10.1038/s41591-018-0034-6 ...
Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov. 2006 Jan;5(1):37-50. Review CB Yoo,PA Jones - 《Nature Reviews Drug Discovery》 被引量: 2237发表: 2006年 Epigenetic Cancer Therapy Makes Headway Mack GS. GS Mack - 《J Natl Cancer Inst》 被引量: 253发表:...