epigenetic drugs have evolved in terms of their specificity and efficiency, especially because of the possibility of using more effective transport and delivery systems. The use of nanoparticles (NPs) in oncology management offers
which can function as either tumor suppressor gene or oncogene depending on the cancer type, is worthy of particular mention. It is the enzymatic subunit of polycomb repressive complex 2 (PRC2) which is involved in maintaining the transcriptional repressive state of genes through methylation on hist...
Understanding the extent of epigenetic changes occurring in RCC and the mechanisms by which they influence disease progression and treatment response, as well as knowledge of current research on biomarkers and treatments, is crucial to successful clinical translation of epigenetics in RCC....
The goal of this review is to present clinical applications of epigenetics in cancer and CVDs. Additionally, we discuss how NM can gradually be advanced from the bench to bedside via epigenetics. With this overview, we provide information and insights for both basic scientists and physicians who ...
The goal of this review is to present clinical applications of epigenetics in cancer and CVDs. Additionally, we discuss how NM can gradually be advanced from the bench to bedside via epigenetics. With this overview, we provide information and insights for both basic scientists and physicians who ...
1868-7075 Clinical Epigenetics 医学1区 0959-8049 EUROPEAN JOURNAL OF CANCER 医学1区 2095-0217 Frontiers of Medicine 医学1区 2211-3428 CELLULAR ONCOLOGY 医学2区 0022-3417 JOURNAL OF PATHOLOGY 医学1区 2044-5385 Blood Cancer Journal 医学1区 ...
(NCT04856774). To fully understand the mechanism of resistance to immunotherapy, factors such as epigenetics, metabolism, immune suppression, and microbiota must be considered. Therefore, the development of combined therapies should be based on understanding the underlying mechanisms of immune modulation ...
c. Epigenetic drug decitabine inhibits DNA methylation, acts on depleted T-cells associated with epigenetics [21,22], enables depleted T-cells to be reversed as long-lasting functional memory T-cells, inhibits the obstruction of depleted T-cells in immune system control infections and tumors, and...
(NCT04856774). To fully understand the mechanism of resistance to immunotherapy, factors such as epigenetics, metabolism, immune suppression, and microbiota must be considered. Therefore, the development of combined therapies should be based on understanding the underlying mechanisms of immune modulation ...
We focus on the emerging potential for the bench-to-bedside translation of some of these epigenetic alterations into clinical practice and discuss the burgeoning evidence supporting the potential of emerging epigenetic therapies in CRC as we usher in the era of precision medicine....