Epigenetics is defined as a series of biological processes involving chromatin-mediated DNA template regulation, independent of changes in the original DNA sequence [8]. Protein complexes that control epigenetic modifications (including DNA methylation and covalent histone modification) can be divided into ...
which can function as either tumor suppressor gene or oncogene depending on the cancer type, is worthy of particular mention. It is the enzymatic subunit of polycomb repressive complex 2 (PRC2) which is involved in maintaining the transcriptional repressive state of genes through methylation on hist...
Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations聽 used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosisDumitrescu, Ramona G...
Cancer epigenetics in clinical practice 收稿日期:2022年8月19日;录用日期:2022年10月20日;发布日期:2022年12月13日 从收到稿件到接受稿件用时:2.0个月 文章六: Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer 收稿日期:2022年10...
The goal of this review is to present clinical applications of epigenetics in cancer and CVDs. Additionally, we discuss how NM can gradually be advanced from the bench to bedside via epigenetics. With this overview, we provide information and insights for both basic scientists and physicians who ...
1868-7075 Clinical Epigenetics 医学1区 0959-8049 EUROPEAN JOURNAL OF CANCER 医学1区 2095-0217 Frontiers of Medicine 医学1区 2211-3428 CELLULAR ONCOLOGY 医学2区 0022-3417 JOURNAL OF PATHOLOGY 医学1区 2044-5385 Blood Cancer Journal 医学1区 ...
(NCT04856774). To fully understand the mechanism of resistance to immunotherapy, factors such as epigenetics, metabolism, immune suppression, and microbiota must be considered. Therefore, the development of combined therapies should be based on understanding the underlying mechanisms of immune modulation ...
The advent of immunotherapy has made an indelible mark on the field of cancer therapy, especially the application of immune checkpoint inhibitors in clinical practice. Although immunotherapy has proven its efficacy and safety in some tumors, many patient
We focus on the emerging potential for the bench-to-bedside translation of some of these epigenetic alterations into clinical practice and discuss the burgeoning evidence supporting the potential of emerging epigenetic therapies in CRC as we usher in the era of precision medicine....
Tumor-associated macrophages (TAMs) are the main immune cells in the context of CRC. Epigenetics affect the production, recruitment and exhaustion of TAMs and reprogram TAMs to promote or inhibit tumors. Studies have shown that in a coculture system of macrophages and CRC cells, the use of EZH...