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Epizyme Scientists Detail Epigenetic Approaches To Cancer Therapy In Drug Discovery TodayEpizyme, Inc
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The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adop
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancerEpigenetic dysregulation is a common feature of most cancers, often occurring directly through alteration of epigenetic machinery. Over the last several years, a new generation of drugs directed at epigenetic modulators ...
Epigenetic approaches to cancer therapy Histone deacetylation and DNA methylation have a central role in the control of gene expression, including transcriptional repression of tumour suppressor ... JA Plumb,N Steele,PW Finn,... - 《Biochem Soc Trans》 被引量: 79发表: 2004年 Epigenetic Approaches...
Researchers studying cancer epigenetics therapies dream of days when we might be able to control DNA methylation like our car stereos…less treble, little more bass. 5 Aza is one of the early leaders in the epi pipeline, and like a lot of therapeutics out there, we learn more about how it...
The molecular basis of cancer encompasses both genetic and epigenetic alterations. These epigenetic changes primarily involve global DNA methylation change
More information:Lu Wang et al. Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy,Nature Medicine(2018).DOI: 10.1038/s41591-018-0034-6 Fei Xavier Chen et al. Born to run: control of transcription elongation by RNA polymerase II,Nature Reviews Mole...
which frequently results in a rapid acquisition of therapy resistance. Besides resistance-conferring genetic alterations within a tumor cell population selected during drug treatment, recent findings also reveal non-mutational mechanisms of drug resistance, involving a small population of “cancer stem cells...