Finally, we will discuss the potential of DNA methylation changes as biomarkers to be used in diverse areas of cancer treatment, especially for predicting response to treatment with DNMT and HDAC inhibitors. 展开 关键词: Epigenetics Cancer therapy Epi-drug Histone deacetylase inhibitor DNA ...
The article focuses on a report by the pharmaceutical experts GBI Research which states emergence of epigenetics as a key determinant of cellular differentiation which will play a vital role in several human diseases. It mentions that epigenetics refers to a selective regulation of gene expression ...
Epigenetics and cancer treatment EpigeneticsCancer therapyEpi-drugHistone deacetylase inhibitorDNA methyltransferase inhibitorIn addition to the genetic alterations, observed in cancer cells, are ... LS Kristensen,HM Nielsen,LL Hansen - 《European Journal of Pharmacology》 被引量: 483发表: 2009年 Epigenet...
The emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of their specificity and efficiency, especially because of the possibility of using more effective ...
Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects. World J Gastroenterol. 2014;20(24):7830-48. doi:10.3748/wjg.v20.i24.7830.Neureiter, D., Jager, T., Ocker, M. & Kiesslich, T. Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects. World ...
During the initiation, development, and progression of cancer, a number of genes undergo epigenetic changes. Some of these changes can be used as biomarkers for early detection of cancer as well as to follow treatment. A panel of epigenetic biomarkers is preferred to a single biomarker in ...
Angela Ting, Ph.D., was intrigued by the field of epigenetics as soon as she was introduced to it in college. Now, she runs a research lab that explores how epigenetics plays a role in the development of cancer. She wants to use that knowledge to better
An improvement in pancreatic cancer treatment represents an urgent medical goal.Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades.Increasing knowledge about the molecular pathogenesis of the dise...
Alterations in chromatin function and epigenetic mechanisms are a hallmark of cancer. The disruption of epigenetic processes has been linked to altered gene expression and to cancer initiation and progression. Recent cancer genome sequencing projects rev
epigenetics and animal models: applications in cancer control and treatment chapter outline Infectious agents are one of the factors which contribute to cancer development. Few examples include human papilloma virus in cervical cancer, hepatitis v... M Verma,N Agarwal,M Verma 被引量: 3发表: 2014...