(AR). A member of a family of proteins called nuclear receptors which bind lipophilic steroid molecules. AR interacts with androgens, binds to androgen receptor element (ARE), and causes transcription activation of its target genes; it is a common target of therapy for prostate cancer. ...
It has been shown re-expression of tumor suppressor genes in tumor cells suppresses cell growth or can cause changes in cell sensitivity to anti-cancer therapy. Although this proved to be heredity, but their reversibility, has opened many hopeful windows for treatment. Some compo...
The promise and failures of epigenetic therapies for cancer treatment Genetic mutations and gross structural defects in the DNA sequence permanently alter genetic loci in ways that significantly disrupt gene function. In shar... Bojang,Ramos,S K. 被引量: 0发表: 0年 Epigenetic therapies for chemor...
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as an ablative therapy. Unfor...
Epigenetic dysregulation is often linked to human disease, notably cancer. With the development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited viable therapeutic potential for solid tumors in ...
The microenvironment in breast cancer progression: biology and implications for treatment Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized a... AE Place,SJ Huh,K Polyak - 《Breast Cancer Research Bc...
Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune therapy. Herein, pharmacologic and isoform specificity of HDACis are investigated to guide their addition to a DNMTi, thus devising a ...
Prostate cancer is one of the most commonly diagnosed cancers in men. The number of affected men is expected to rapidly increase as the population of males... Wang - 《International Journal of Oncology》 被引量: 60发表: 2010年 Epigenetic drugs for cancer treatment and prevention: mechanisms of...
Precisely how the treatment works isn't yet known. And because drugs that remove methyl groups from DNA can potentially switch on hundreds of genes in healthy cells, including known oncogenes, there is concern that the drugs could cure one kind of cancer but cause another. 展开 关键词: ...
Nature Reviews Cancer19,151–161 (2019)Cite this article 26kAccesses 371Citations 165Altmetric Metrics Abstract DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that ...