Recent studies have also suggested that epigenetic deregulation in stem cells could play an important role in carcinogenesis, and new models have been suggested for the attainment of tumourigenesis and bypass of senescence. Overall, proper regulation of the chromatin environment is suggested to have an...
it is currently generally accepted to refer to changes in gene activity independent of the primary DNA sequence. In some definitions, only the modification of activity states inherited across cell division is considered, consistent with an important role in the regulation of proliferative cells in the...
et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7, 380–390 (2010). Article PubMed PubMed Central CAS Google Scholar Takubo, K. et al. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell...
Three age-dominant branches were identified, and C0, C1 and C2 were located at the key hub of the age dynamics transition (Fig. 2e). Notably, we found that the pseudo-temporal expression of most ADEM genes coincided with the up- or down-regulation trend (Fig. 2f), confirming that ADEM...
MeCP2 mutation was first identified as the primary cause of the neurological Rett syndrome (RTT) by Amir et al. [16]. Our former work found senescent EPCs had elevated MeCP2 expression and decreased SIRT1 expression [17]. Now we will illuminate the epigenetic regulation of MeCP2/SIRT1 ...
MeCP2 reduced angiogenesis of senescent EPCs, promoted apoptosis, and caused senescent EPC dysfunction through SIRT1 promoter hypermethylation and histone modification. MeCP2 mediated senescent EPC dysfunction through epigenetic regulation. 展开 关键词: Endothelial progenitor cells Senescence MeCP2 SIRT1 ...
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat. Rev. Mol. Cell Biol. 16, 593–610 (2015). CAS PubMed PubMed Central Google Scholar Sen, P., Shah, P. P., Nativio, R. & Berger, S. L. Epigenetic mechanisms of longevity and aging. Cell 166,...
I will also examine how the cellular interferon-inducible protein 16 (IFI16) plays a role in sensing of herpesviral DNA and in integrating the induction of innate responses and epigenetic silencing of the viral DNA. Epigenetic regulation of herpes simplex virus lytic and latent infection HSV ...
activities in comparison to non-lineage committed progenitors, along with more persistent 53BP1 foci. Moreover, the DNA repair process in hHSCs needs the presence of thrombopoietin, which supports important microenvironmental factors in the regulation of hHSCs IR exposure response98. Keratinocyte and ...
Senescent vascular cells are detected in atherosclerotic lesion, and its involvement in the development of atherosclerosis has been revealed; however, whether and the mechanism by which endothelial cell (EC) senescence is causally implicated in atheroscl