epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases.A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related ...
Epigenetic regulation of aging:implications for interventions of aging and diseases Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-as... K Wang,H Liu,Q Hu,... - 信号转导与靶向治疗(英文) 被...
In this review, we introduce the history and four general mechanisms of epigenetic modulation and systematically summarise recent progress regarding the roles of epigenetic regulation in metabolic diseases as well as the underlying mechanisms. Besides, we discuss the clinical applications of epigenetic regu...
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat. Rev. Mol. Cell Biol. 16, 593–610 (2015). CAS PubMed PubMed Central Google Scholar Sen, P., Shah, P. P., Nativio, R. & Berger, S. L. Epigenetic mechanisms of longevity and aging. Cell 166,...
Epigenetic regulation of caloric restriction in aging. BMC Medicine. 2011;9(1):98.Li, Y.; Daniel, M.; Tollefsbol, T. O. Epigenetic regulation of caloric restriction in aging. BMC Med. 9:98; 2011.Li, Y. et al. (2011) Epigenetic regulation of caloric restriction in aging. BMC Med....
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat. Rev. Mol. Cell Biol. 16, 593–610 (2015). Article CAS PubMed PubMed Central Google Scholar Siebold, A. P. et al. Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress ...
Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo? J. Biol. Chem., 279 (...
Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction. Nucleic Acids Res 2002 ; 30:2365; http://dx.doi.org/ 10.1093/nar/30.11.2365 ;... Barbot,W. - 《Nucleic Acids Research》 被引量: 0发表...
Epigenetic regulation of drug metabolism in aging: utilizing epigenetics to optimize geriatric pharmacotherapy We explore the relationship between epigenetic aging and drug metabolism. We review current evidence for changes in drug metabolism in normal aging, follow... S Abudahab,PW Slattum,ET Price,....
Epigenetic regulation by G9a/GLP complex ameliorates amyloid‐beta 1‐42 induced deficits in long‐term plasticity and synaptic tagging/capture in hippocampal... M Sharma,T Dierkes,S Sajikumar - 《Aging Cell》 被引量: 3发表: 2017年 Control of Cognition and Adaptive Behavior by the GLP/G9a ...