Further functional study suggests that RRAD up-regulation acts as a negative feedback mechanism to counter cellular senescence by reducing the level of reactive oxygen species. Finally, we found both p53 and NF-魏B bind to RRAD genomic regions and modulate RRAD transcription. This study established...
Overexpression or activation of SIRT1 significantly reduces the IR-induced senescence phenotype, whereas inhibition of SIRT1 activity induces senescence. Based on these findings, we propose that IR induces cellular senescence of articular chondrocytes by negative post-translational regulation of SIRT1 via ...
In this study, we have applied the kinetic theory of substrate reaction during modification of enzyme activity to study the regulation mechanism of PAK2 activity by the catalytic subunit of protein phosphatase 1 (PP1α). On the basis of the kinetic equation of the substrate reaction during the...
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. UsingSirt1-deficient mice, we found thatSirt1andPeriod 2(Per2) constitute a reciprocal negative regulation loop that plays important ...
For further evaluation of UCP2 regulation by TGFb/SMAD, the 3 kb human UCP2 promoter was analyzed by Vector NTI Suite software (Invitrogen, Carlsbad, CA, USA). Over 20 putative RSBE-like sites were revealed, and 5 regions that displayed the highest density of such sites are shown dia...
cells. Other mutants with deletions in two other sites (position A and B) did not show reduced luciferase activity (Figure 3C). These results indicate that binding sites in the -150 region upstream of the transcription start site is responsible for transcriptional regulation of FOXQ1 by BCL6....
Negative Regulation of CEBPbeta1 by Sumoylation in Breast Cancer Cells 英文参考文献.doc,NegativeRegulationofC/EBPbeta1bySumoylationin BreastCancerCells AllisonA.Atwood1,RachelJerrell2,LindaSealy1,2* 1DepartmentofCancerBiology,VanderbiltUniversitySchoolof
Cellular senescence is an irreversible growth arrest caused by different types of cellular stress [10, 37]. The role of senescence as a terminal cell fate following cancer therapy has evolved over the last decade. While in some situations, senescence may be a favorable cell fate (CDK4/6i) ...
Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review...
In this study in peanut (Arachis hypogaea), we demonstrate that ABA biosynthesis is also controlled by negative feedback regulation, mediated by the inhibitory effect on AhNCED1 transcription of a protein complex between transcription factors AhNAC2 and AhAREB1. AhNCED1 was significantly down-...