This chapter describes how our knowledge on cellular senescence evolved over the past decades. The different concepts of cellular senescence including developmental, replicative, and stress-induced senescence are discussed. The functional significance of these different types of senescence is highlighted by ...
Results: The number of senescence-associated beta-galactosidase positive cells (8.3% +- 1.9% vs 2.2% +- 0.8%; P = .008) and the level of cellular fibronectin protein (455.7 +- 80 vs 210 +- 51; P = .04) and messenger RNA (16.8 +- 6.8 vs 13.5 +- 5.7; P = .042) were ...
Glioblastoma (GBM) is the most malignant, aggressive and recurrent primary brain tumor. Cell senescence can cause irreversible cessation of cell division in normally proliferating cells. According to studies, senescence is a primary anti-tumor mechanism
英文关键词:AgingBiomarkersCellular senescenceHealth impact assessment 基金项目: 摘要点击次数:3606 全文下载次数:2552 中文摘要: 衰老是一种适应和受调控的过程,可能还伴随有害事件随机累积的结果,最终导致机体健康状况下降、患病风险增加和死亡。随着衰老的研究,衰老的部分意义被阐述,衰老的复杂特征轮廓渐明了。衰老的...
These programmed cell fate decisions include true cell death (apoptosis-necroptosis) and therapy-induced cellular senescence (TIS), a permanent "proliferative arrest" commonly portrayed as premature cellular aging. Despite a permanent loss of...
Lei et al. [69] treated human mesenchymal stem cells with ASC-derived exosomes and significantly reduced the expression levels of typical indicators associated with cellular senescence, including β-galactosidase activity, p16, p21, IL-8 and IL-1β. In a mouse model of osteoarthritis, intra-...
Cell vitalities were measured by CCK8.Phenotypes and ROS of mBM-MSC were analyzed by flow cytometry.Cellular senescence was detected by SA-β-gal stains.IL-6 and CXCL1 secretions were measured by ELISA.Results:Our study showed that cell vitalities of mBM-MSC were reduced after IFN-γ...
Lipids as Regulators of Cellular Senescence 2022, Frontiers in Physiology Regulation of intestinal lipid metabolism: current concepts and relevance to disease 2020, Nature Reviews Gastroenterology and Hepatology p53 as a regulator of lipid metabolism in cancer 2016, International Journal of Molecular Science...
Aging is a complex biological process characterized by several hallmark features such as chronic inflammation, genomic instability, epigenetic alterations, cellular senescence and mitochondrial dysfunction, leading to deterioration in function [1]. It is one of the leading risk factors for many chronic di...
Cellular senescence is characterized by irreversible cell cycle arrest that can be induced by a variety of stresses, including oxidative stress, oncogene expression, mitochondrial dysfunction, and telomere shortening, among others. Senescent cells have been shown to accumulate in a variety of tissues wit...