Many of the later only became evident when senescent cells were directly targeted and eliminated through senolytic approaches. How such senotherapies may become novel strategies to improve transplant outcome is presented. In addition to discussing the therapeutic potential derived from the interaction with...
Regression analysis showed that senescent features of CD4 and CD8 T cells in patients were influenced by donor age and the frequency of CD28 cells, respectively. Conclusion Our data suggest that in paediatric HaploSCT, premature immunosenescent changes occur in T cells from parental donors, and ...
5-Bromodeoxyuridine Induces Senescence-Like Phenomena in Mammalian Cells Regardless of Cell Type or Species 5-Bromodeoxyuridine was found to induce flat and enlarged cell shape, characteristics of senescent cells, and senescence-associated /J-galactosidase in mam... Michishita,Eriko,Kazuhiko,... - 《...
At the time of surgery abdominal subcutaneous adipose tissue from adjacent sites was removed by excision and needle aspiration. Stromovascular cell composition (flow cytometry), the number of senescent cells (senescence-associated-β-galactosidase staining) and interleukin (IL)-6, IL-1, TNF-α and...
.111An increase in inflammatory transcripts (NCF2 and NCF4 for neutrophils, MgL2 and MSR2 for macrophages and KLRB1 and KLRD1 for NK cells) was also noted. In this model, the participation of the innate immune system was shown to be determinant for the efficient clearance of senescent tumor...
MSCs tend to become senescent after injection due to crosstalk with the microenvironment, which hinders their clinical application and leads to undesirable therapeutic effects. MSCs become senescent with increased expression of senescence-associated genes during long-term in vitro culture and due to replic...
Considering the pathophysiological condition of age-related skeletal muscle loss from the molecular biological mechanism of aging, senescence is associated with advanced aging in humans. Senescent cells involving irreversibly proliferative arrest can develop the SASP, consisting of proinflammatory cytokines and...
Although a general mechanism for the limited responsiveness of senescent cells has yet to be established, reduced responsiveness may in part be ascribed to... EJ Yeo,CP Sang - 《Mechanisms of Ageing & Development》 被引量: 140发表: 2002年 Effects of specific prostanoid EP receptor agonists on...
Recently, a study carried out by multiple teams in the United States, France, and the UK cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells, and suggested that ORF10 of SARS-CoV-2 shows limited homology with that of SARS-CoV. The study found that ORF10 of...
Since senescent cells remain vital, it is critical to understand their long-term fate and ultimate impact on outcome. Given the potential reversibility of senescence by additional genetic events, assessment of a senescence-associated tumorigenic capability appears to be crucial for the development of ...