The discovery has the potential to lead to therapies which could help people age better, without experiencing some of the degenerative effects of getting old. Most people by the age of 85 have experienced some kind of chronic illness, and as people get older they are more prone tostroke,heart...
Mesenchymal stem cells (MSCs) from extraembryonic tissues are easily collected before, during and after the birth, without requiring invasive procedures or experiencing ethical limitation in comparison with those associated with their adult and embryonic counterparts [18]. In this study, we propose MSCs...
while the number and function of Th2 cells show an increasing trend. This imbalance in the ratio of Th1 to Th2 cells can lead to tumor metastasis [139]. Lucia et al. suggest that the ratio of anti-tumor Th1 cells to pro-tumor Th2 cells may have clinical...
The vulnerability of pregnant women to infectious disease has been explained historically by assuming that the immune system weakens during pregnancy so that it can tolerate the fetus. Indeed, the maternal immune system does not reject the fetus or its placenta despite being aware of fetal antigens...
A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array ...
A headspace gas composition containing 3% O2 was chosen as it would result in the cells within the culture medium experiencing physiological oxygen levels. The oxygen concentration in the headspace is higher than that experienced by the cells due to the difference in oxygen solubility between the ai...
The relationship between LNAC-mediated blockade of p21CIP1 induction and these events is unclear, although the recent finding that LNAC-related attenuation of ROS generation blocked p21CIP1-associated growth arrest and senescence in normal and neoplastic cells52 may be relevant. While the ...
Specifically, after experiencing stress, terminal cells that are relatively prone to senescence can escape through polyploid-related dedifferentiation and genomic instability, while undifferentiated cells that are relatively resistant to senescence rely on cellular remodeling to initiate senescence bypass, ...
The highest levels of serum IL-6 were detected during the first 5 days after CAR-BCMA T-cell infusion, which was also the time when patients were experiencing the most toxicity. Patients 10 and 11 had by far the highest levels of serum IL-6 and the most severe toxicity. In addition ...
Both the medulla and cortex of the kidney undergo senescence when AKI develops comprising vascular smooth muscle cells, TECs, endothelial cells, interstitial as well as podocytes cells, with TECs being the most frequent cells experiencing senescence and sensitive to injury.9,10,14,15 Senescence of ...