Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells ha
In this review, we address the challenge of identifying resident adult stem cells, as well as the role they play within the salivary gland during homeostasis and regeneration. Initially presenting salivary gland stem/progenitor cells within the context of the quiescent, multipotent “traditional” stem...
There is no single, stand-alone marker that allows the identification of senescent cells, posing a challenge to their identification and targeting. ... Passos Joao - Innovation in Aging 被引量: 0发表: 2024年 Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for...
Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark ). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark cell detection together with ...
Due to the complexity of FOP, the diagnosis remains a challenge for endocrinologists. Sharing relevant information about FOP researches can help to improve accessibility of care and address these challenges [23]. In 2006, it was determined that the causative variant of FOP was ACVR1/ALK2 gene ...
To check if the presence of senescent cells influences the limb regeneration process, researchers in the Yun group found a way to modulate the number of senescent cells in the wound. The team observed that the presence of senescent cells enhanced the regeneration process. ...
In the current study, we investigated the effect of senescent cells on the motility of breast cancer cells, which is another key step in cancer cell metastasis. We analyzed the motility of breast cancer cells co-cultured with senescent cells in vitro and metastasis of the breast cancer cells ...
However, the multiple origins and thus heterogeneity of the CAF population suggest the challenge of identifying an appropriate anti-CAF therapeutic target and highlights the importance of understanding the biological contributions of CAFs from each origin. Using a unique clonal cell transplantation method,...
Therapeutic targeting of senescent cells in the CNS 中枢神经系统衰老细胞的治疗靶向 网址 https://www.nature.com/articles/s41573-024-01033-z.pdf DOI 10.1038/s41573-024-01033-z 复制 doi 其它 期刊:Nature Reviews Drug Discovery 作者:Markus Riessland; Methodios Ximerakis; Andrew A. Jarjour; ...
Of particular interest for such treatments are the ‘senescent’ cells that accumulate with age — cells that have stopped dividing and instead become seemingly dormant, in a state of arrested growth1. But it has proved challenging to isolate senescent cells, preventing researchers from fully ...