Park SC, Cho KA, Jang IS, Kim KT, Ryu SJ (2004) Functional efficiency of the senescent cells: replace or restore. Ann NY Acad Sci 1019:309–316Park SC (2004) Phenotypic adjustment of senescent cells: replace or restore. Geriatr Gerontol Int 4:517–520...
Cerebellum locates in the hindbrain region and consists of highly dense and complex neuron networks in the human brain1. It is challenging to derive human brain cerebellar-like spheroids/organoids with similar biomarkers and function from human pluripotent stem cells (hPSCs), including both human ind...
Specifically, EMT is a process by which epithelial cells lose polarity and cell-cell adhesion while gaining mesenchymal characteristics such as migratory capacity17. These changes are associated with the downregulation of epithelial markers such as E-cadherin and miR200 microRNA family and the upregula...
Common variable immunodeficiency (CVID) is a heterogeneous group of diseases. Our aim was to define sub-groups of CVID patients with similar phenotypes and clinical characteristics. Using eight-color flow cytometry, we analyzed both B- and T-cell phenotypes in a cohort of 88 CVID patients and ...
The reasons for this are unclear, but is likely influenced by differences [8] in experimental techniques (ALI versus submerged cultures) and clinical characteristics of asthmatic subjects from whom the primary HAECs were derived (severe asthmatic subjects in our study versus mi...
ed pulmonary vascular remodeling is accompanied by the acquisition and maintenance of a modified pro-proliferative apoptosis-resistant phenotype in the various contractile vascular cells in the arterial wall, including PA-SMCs, adventitial fibroblasts, and cells expressing myofibroblast-like characteristics....
(Table1). Contrary to the first passage experiment, no isolates withnwtmorphology or senescence were observed at the moment they were cultured out of the hosts in which they were inoculated. However, punctuated growth patterns, one of the common characteristics of thenwtphenotype, were observed ...
Park SC, Cho KA, Jang IS, Kim KT, Ryu SJ (2004) Functional efficiency of the senescent cells: replace or restore. Ann NY Acad Sci 1019:309–316Park SC (2004) Phenotypic adjustment of senescent cells: replace or restore. Geriatr Gerontol Int 4:517–520...
These cells were defined CSCs because they share with stem cells biological characteristics like the unlimited capability to grow3. This observation changes completely the therapeutic perspective since the only way to eradicate the tumor is to target CSCs28. Yet, the identification of the best ...
Stem cells have unique metabolic characteristics that play an essential role in maintaining their self-renewal and multi-potentiality. Human mesenchymal stem cells (hMSCs) are a primary cell source in cell therapy for a wide range of diseases. However, culture induced changes in hMSC phenotype ...