Biomarkers of senescent cell burden, including molecular signals in circulating immune cells and the abundance of circulating senescence-related proteins, have been associated with chronological age and clinical parameters of biological age in humans. The extent to which senescence biomarkers are affected ...
baicalin inhibited the viability of HCT116 and SW480 colon cancer cells (Fig.1a). To further validate whether the inhibition of cancer cells mediated by baicalin is due to its induced senescence in human colon cancer cells, HCT116 and SW480 treated with baicalin at different...
This is not the case for p21CIP1, which is necessary for cellular senescence in humans but not in mice [89]. However, p21CIP1-deficient mice are more predisposed to develop tumors [90]. Moreover, the relevance of p53 as a tumor suppressor is confirmed by its frequency of mutations in ...
Cellular senescence can be classified into two primary types: replicative and stress-induced premature senescence [4]. Replicative senescence primarily occurs due to telomere shortening and a decrease in telomerase activity, eventually leading to reaching the Hayflick limit [5]. Stress-induced premature ...
根据第四段的Last year,LeBrasseur led a study that provided the first sign in humans that exercise greatly affected senescence.(去年,LeBrasseur领导的一项研究首次在人类身上发现了运动对衰老有很大影响的迹象。)可知,LeBrasseur领导的一项研究首次在人类身上发现了运动对衰老有很大影响的迹象。即他是证明运动...
Cellular senescence, the irreversible proliferative arrest seen in somatic cells after a limited number of divisions, is considered a crucial barrier to cancer, but direct evidence for this in vivo was lacking until recently. The best-known form of human cell senescence is attributed to telomere sh...
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in response to endogenous and exogenous stresses, including ...
HIV-1 viral protein R (Vpr) can induce cell cycle arrest and cell death, and may be beneficial in cancer therapy to suppress malignantly proliferative cell... - 《Apoptosis》 被引量: 46发表: 2009年 Prohibitin and the senescent phenotype Its involvement in senescence has been postulated from ...
Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 proteins. In particular, upon longer IFN-β treatments, cutaneous HPV38 expressing cells undergo senescence. IFN-β ...
characteristic signature of senescence based on the expression of 31 genes in mice and ensured that it was identical in humans. "We observed that the strong expression of this signature was associated with a poor prognosis," adds Alexa Saliou. "This shows the pro-tumoraction of senescence in ...