Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017; 13(2):77-89. https://doi.org/10.1038/nrneph.2016.183 PMID: 28029153.Sturmlechner I, Durik M, Sieben CJ et al (2017) Cellular senescence in renal ageing and disease. Nat Rev Nephrol 13:77-89. https://doi. org...
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting thes
20] (Fig.1). In IR-induced acute and chronic tissue damage/dysfunction, cellular senescence is of great significance. In general, senescence can be divided into replicative senescence and premature senescence [21](Fig.2). Different from replicative senescence...
Morescientistsareresearchingcellularsenescence(细胞衰老)—astateinwhichcellsnolongerdivide.Senescentcells,whichbuildupinolderbodies,havesomethingtodowithage-relatedconditionssuchasdementia(痴呆)disease.Scientistsareresearchingdrugsthattreatsenescentcells.Butthemostpromisingtoolagainstthebadinfluencesofsenescentcells,experts...
senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking. results we develop cell...
The excessive accumulation of senescent cells in various tissues correlates well with age-related metabolic disorders and the development of premature chronic disease [35]. Of note, concomitant with cellular senescence, another common feature of ageing-related conditions is persistent low-grade sterile ...
senescence-messaging secretome B. Role of Senescence in Evolution and Different Organisms (……) C. Causes and Effector Pathways of Senescence telomere shortening最重要的原因 端粒酶在端粒缩短的过程中并不能完全的修复缩短的端粒,因此会导致端丽损伤。
Chronic kidney disease (CKD) is increasingly being accepted as a type of renal ageing. The kidney undergoes age-related alterations in both structure and function. To date, a comprehensive analysis of cellular senescence and senescence-associated secretory phenotype (SASP) in CKD is lacking. Hence,...
Precise modulation of cellular senescence may contribute to improve liver diseases. View article Epigenetics in Health and Disease - Part A Sarita Mishra, ... Anand Krishna Tiwari, in Progress in Molecular Biology and Translational Science, 2023 2.5 Cellular senescence Cellular senescence is the respon...
However, recent discoveries in molecular biology have revealed that microRNAs (miRNAs) are potential indicators of aging, cellular senescence, and Alzheimer's disease (AD). The purpose of our chapter is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging, ...