Cellular senescence in cardiac diseasesCellular senescenceHeart failureSenolysisReplicative capacity of somatic cells is limited. It indicates that aging also develops at the cellular level, and this is described as "cellular senescence". Senescent cells become flattened, enlarged, and irreversibly lose ...
Cellular senescence has evolved from an in-vitro model system to study aging in vitro to a multifaceted phenomenon of in-vivo importance as senescent cells in vivo have been identified and their removal delays the onset of age-associated diseases in a mouse model system. From the large emerging...
In recent years, studies have confirmed that cellular senescence regulates the development and progression of IR-induced acute and chronic diseases in different organs dynamically and reversibly [33]. More and more evidence revealed that genetic and pharmacological clearance of senescent cells could amelio...
Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy. ...
Fig. 1. Triggers, effector pathways and features of senescence in tissue dysfunction, ageing and chronic diseases. Inducers triggering senescence vary depending on the context, including DNA damage, reactive oxygen species (ROS), oncogenic mutations, metabolic insults, proteotoxic stress and other unkno...
Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and proliferation leading to the degeneration of cellular structure and function, has been implicated in various key physiological and pathological processes, particularly in cancer. Initially, CS was recognized as a barrier...
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Palmitate triggers inflammatory responses in sever M Sokolova,LE Vinge,K Alfsnes,... - 《Biochimica Et Biophysica Acta Molecular & Cell Biology of Lipids》 被引量: 0发表: 2017年 加载更多来源期刊 Cellular Signall...
Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, cellular senescence has many physiological fu
Cell senescence in cardiometabolic diseases Article Open access 21 October 2024 References Lakatta EG and Levy D (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a “set up” for vascular disease. Circulation 107: 139–146 Artic...
Baicalin is a natural flavonoid glycoside which has potent anti-tumor and antioxidant activity in cancer cells. In the present study, we found that baicalin treatment significantly induced senescence in colon cancer cells. Furthermore, baicalin upregulat