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Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in response to endogenous and exogenous stresses, including ...
Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both physiologically and pathologically. While phenotypically div...
The development of osteoarthritis (OA) correlates with a rise in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been implicated in cartilage degradation and OA. Age-related mitochondrial dysfunction and associated oxidative stress might induce...
cell senescencecellular mechanismsstress responsemicrogravitySHOCK-PROTEIN HSP70MOLECULAR CHAPERONESLIFE-SPANSUPPRESSIONFATEMesenchymal stem cells are undifferentiated ... R Pala,S Cruciani,A Manca,... - 《International Journal of Molecular Sciences》 被引量: 0发表: 2023年 Bone marrow-derived mesenchymal st...
Intervertebral disc degeneration (IDD) is a chronic, complex process associated with low back pain; mechanisms of its occurrence have not yet been fully el... S Wang,Y Rui,J Lu,... - 《Cell Prolif》 被引量: 118发表: 2014年 Disc cell senescence in intervertebral disc degeneration: Causes...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associa...
Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous biologically active molecules collectively known as the senescence-associated secretory phenotype, or SAS
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting thes
Characterization of cellular senescence mechanisms in alcoholic liver injury Cellular senescence is a stress‐responsive program limiting the proliferation of damaged cells and leading to stable cell‐cycle arrest. Accumulation of senescent hepatocytes may contribute to loss of functional hepatic mass and ...