These different and oftentimes opposite functional roles are partly explained by recent evidences supporting the concept that the senescence state is an exquisitely dynamic process. In this chapter, we discuss the mechanisms regulating induction and establishment of various senescence programs, with ...
Cells are continuously exposed to various stress factors that endanger their functionality and thus, their ability to cope with stress. The ability of cells to adapt and survive by restoring homeostasis is an integral component of cellular physiology. However, if the stress is persistent and homeosta...
leading to continuous heart failure, even in people without a prior history of heart disease. To address this issue and improve cardiac cell function, it is crucial to investigate the molecular mechanisms underlying cardiac senescence. This review...
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in respons
Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS. Abnormalities in PCD signalling cascades
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to agi...
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to agi...
J Hematol Oncol (2020) 13:157 https://doi.org/10.1186/s13045-020-00994-z REVIEW Open Access Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches Lei Zhang1, Ryan Mack1, Peter Breslin1,2 and Jiwang Zhang1,3* Abstract Aging ...
An appreciation of how environmental pollutants act on our cells to produce deleterious health effects has led to advances in our understanding of the molecular mechanisms underlying the pathogenesis of chronic diseases, including cancer and cardiovascular, neurodegenerative and respiratory diseases. Here, ...
Cellular senescence in ageing: from mechanisms to therapeutic opportunities Article 16 December 2020 Cellular senescence: the good, the bad and the unknown Article 03 August 2022 Emerging insights in senescence: pathways from preclinical models to therapeutic innovations Article Open access 22 Nove...