These different and oftentimes opposite functional roles are partly explained by recent evidences supporting the concept that the senescence state is an exquisitely dynamic process. In this chapter, we discuss the mechanisms regulating induction and establishment of various senescence programs, with ...
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in respons
leading to continuous heart failure, even in people without a prior history of heart disease. To address this issue and improve cardiac cell function, it is crucial to investigate the molecular mechanisms underlying cardiac senescence. This review...
The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests the detrimental roles of cell senescence in the pathogenesis of... C Feng,H Liu,M Yang,... - 《Cell Cycle》 被引量: 45发表: 2016年 Molecular mechanisms involved in intervertebral disc degeneration and ...
Recent studies have shown that umbilical cord mesenchymal stem cells have an anti-aging effect in ovaries, but the cellular and molecular mechanisms of HA-MSC ovarian anti-aging remain to be studied. Therefore, we conducted a 10X Genomics single-nucleus
The participation of molecular chaperones in the process of senescence and in the mechanisms of age-related diseases is currently under investigation in ma... L Brocchieri,ECD Macario,AJL Macario - 《Mechanisms of Ageing & Development》 被引量: 55发表: 2007年 Cellular and molecular mechanisms...
Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to agi...
An appreciation of how environmental pollutants act on our cells to produce deleterious health effects has led to advances in our understanding of the molecular mechanisms underlying the pathogenesis of chronic diseases, including cancer and cardiovascular, neurodegenerative and respiratory diseases. Here, ...
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Antibody labeling of tissues has been widely used to interrogate the specific cellular architecture and underlying molecular mechanisms of biological processes. Therefore, we next applied SHANEL to assess the possibility of antibody-based histology of centimeters-sized human tissues. Toward this goal, we...