Regulation of cellular senescence by the retinoblastoma pathway. In: Kaul, S.C., Wadhwa, R. (Eds.), Ageing of Cells In and Outside the Body. Kluwer Academic Publishers, The Netherlands, pp. 151-169.Becker, T.M. and Rizos, H. 2003. Regulation of cellular senescence by the ...
We also analyzed cell division during the acute induction of senescence. To this end, cells were seeded in 96 wells per plate at a concentration of one to four cells per well. Clones were then grown in 3% fetal bovine serum (FBS) or treated with sn38 for 6 days. A resistant clone ...
inflammation, proliferation, and resolution/remodeling. Cellular senescence promotes wound healing; however, diabetic wounds exhibit low levels of senescent factors and accumulate senescent cells, which impair the healing process. Here we show that the number of p15INK4B + PDGFRα + ...
There is increasing evidence for a role of somatic cellular senescence in physiological aging but also in injury and disease. Cell cycle inhibitor p16(INK4a) is the key mediator for stress and aberrant signaling induced senescence. Here we report that elevated blood pressure markedly induced p16(...
Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be ...
Abstract 3217: Regulation of senescence-associated p-Erk1/2 (SA-p-Erk1/2) by PEA-15 and PKC-α in human diploid fibroblastsCellular senescence plays a key role in complicated biological processes, including development, aging, and ... YL Yun,SK Hong,WC Yong,... - 《Cancer Research》 被...
Importantly, in a xenograft mouse model of human colon cancer, we further confirmed that baicalin treatment dramatically inhibited tumor growth, which was due to the induction of tumor cellular senescence via the upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling in vivo. In ...
Telomeres, stem cells, senescence, and cancer Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a... NE Sharpless,RA Depinho - 《Journal of Clinical Investigation》 被引量: 943发表: 2004年...
Regulation of cellular senescence by miR-34a in alcoholic liver injury. Am. J. Pathol. 187, 2788–2798 (2017). Article CAS PubMed PubMed Central Google Scholar Ding, J. et al. Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease....