Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Bai Lin,Deng Xiaoli,Li Juanjuan,Wang Miao,Li Qian,An Wei,A Deli,Cong Yu-Sheng. Cell Research . 2011Bai, L., Deng, X., Li, J., Wang, M., Li, Q., An, W., A, D. and Cong, Y.-S. (2011) ...
This review focuses on the role of transcriptional regulators in the control of cellular senescence, explores how their function is perturbed in cancer and discusses the potential to harness this knowledge for future cancer therapies.关键词: cellular senescence transcription cancer therapy ...
We also analyzed cell division during the acute induction of senescence. To this end, cells were seeded in 96 wells per plate at a concentration of one to four cells per well. Clones were then grown in 3% fetal bovine serum (FBS) or treated with sn38 for 6 days. A resistant clone ...
Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be ...
Abstract 3217: Regulation of senescence-associated p-Erk1/2 (SA-p-Erk1/2) by PEA-15 and PKC-α in human diploid fibroblastsCellular senescence plays a key role in complicated biological processes, including development, aging, and ... YL Yun,SK Hong,WC Yong,... - 《Cancer Research》 被...
Importantly, in a xenograft mouse model of human colon cancer, we further confirmed that baicalin treatment dramatically inhibited tumor growth, which was due to the induction of tumor cellular senescence via the upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling in vivo. In ...
Mutation of p53 is commonly detected in human cancers [10,11]. p53 plays pivotal roles to preserve genomic integrity through surveillance mechanisms against diverse DNA damages, including induction of transient cell cycle arrest for the repair of DNA strand breaks, cellular senescence, and PCD to ...
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence To respond adequately to oxidative stress, mammalian cells elicit rapid and tightly controlled changes in gene expression patterns. Besides alterations in ... K Abdelmohsen,Y Kuwano,HH...
Pathologic diabetic wound healing is caused by sequential and progressive deterioration of hemostasis, inflammation, proliferation, and resolution/remodeling. Cellular senescence promotes wound healing; however, diabetic wounds exhibit low levels of sene