However, recent studies show that senescence could also occur in cancer cells. Cancer cell senescence could occur as a result of chemotherapy, radiation, inhibition of telomerase activity, induction of DNA damage, changes in the tumor microenvironment, regulation of senescence-related proteins...
includingApoe, Cd274/Pd-l1, Fcgr2b, Ifitm3, Ly86, Ptprc/Cd45, and Trem2(Fig.1c–e). We also observed upregulation of genes associated with senescence and the SASP, many of which overlapped with myeloid
Polycomb group (PcG) protein Bmi-1 is an important regulator of cell proliferation. It regulates cellular senescence and proliferation of cells via the tra... WJ Guo,S Datta,V Band,... - 《Molecular Biology of the Cell》 被引量: 374发表: 2007年 Regulation of the potential marker for int...
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells
impeding the development of interventions that might delay or prevent age-related disorders and maximize healthy lifespan. Cellular senescence, which halts the proliferation of damaged or dysfunctional cells, is an important mechanism to constrain the malignant progression of tumour cells1,2. Senescent ...
(Fig.4A), indicating that the elevated exosomal miR-21 expression was caused by the upregulation of cellular miR-21. qRT‒PCR results also confirmed that the expression of miR-21 and pri-miR-21 were higher in GA-MSCs than in BM-MSCs (Fig.S4A), indicating that the transcription of miR...
Regulation of STAT3 in HER2-positive breast cancer. In HER2-positive breast cancer, STAT3 is activated through the EGFR/Src and IL-6/JAK pathways. This leads to abnormally high-level expression of STAT3 in HER2-positive breast cancer. Currently, HER2 inhibitors (trastuzumab, pertuzumab, and lapat...
The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence 2022, Journal of Cellular Biochemistry Transposable elements as new players in neurodegenerative diseases 2021, FEBS Letters Gene regulation by long non-coding RNAs and its biological functions 2021...
Upregulation of miR-378a-5p in M14 melanoma cells reduced both mRNA (Supplementary Fig. 1a) and protein (Supplementary Fig. 1b) levels of STAMBP, SP1, KLF9, FUS-1, and SUFU when compared with control transfected cells, while miR-378a-5p inhibition led to an opposite effect, upregulating...
Additionally, in vivo evidence suggested that injury-responsive cells originate from the PDL3,4,5. However, since the progenitor cell population of adult PDL is highly heterogeneous, it has not yet been defined by specific markers. Furthermore, the regulation of this population remains to be ...