The senescence-related genes were acquired from the CellAge Database and intersected with differentially expressed genes (DEGs) between IDD and control samples for senescence-related DEGs (SRDEGs). Protein-protein interaction (PPI) network analysis was performed to obtain ten hub...
aRelative mRNA expression of senescence-related genes at pre-wound, 2 DPW, and 8 DPW inLeprdb/+and Leprdb/dbmice (n = 7 for each group).b, cPrincipal component analysis (PCA) of the levels of senescence based on senescence-related gene expression at pre-wound, 2 DPW, and 8 DPW ...
At the cellular level, different types of cellular senescence are the basis of cardiac senescence. The replicative capacity of cells is limited, indicating that aging occurs at the cellular level, namely, as “cellular senescence”. Senescent cells exhibit cell cycle arrest, which initiates tissue r...
Indeed, we detected that various aging/senescence-induced genes (ASIGs) were upregulated in malignant diseases compared to healthy control samples. To elucidate the importance of ASIGs during cell development, pseudotime analyses were performed, which revealed a late enrichment of distinct cancer-...
growth factors). The production of this "senescence-associated secretory phenotype" controls a number of biological processes such as wound healing and tissue repair, but also tumor formation and some age-related disorders. But although we know how senescence increases the activity of the genes for...
Although genetic and molecular data point to circadian regulation of many cell cycle-related genes, our findings together with data from animal models clearly place c-Myc at an important junction tying the circadian clock to cancer development. Earlier studies showed that c-Myc affects cell cycle ...
Notably, cells depleted of CBP/p300 acetyltransferase show decreased histone acetylation and exhibit premature senescence, suggesting a strong relationship between senescence and histone acetylation [72]. Finally, studies have also found that promoters of many pro-proliferation genes such as Cyclins A and...
genes are related to the plasma membrane (Fig.3B). In addition, as the symptoms worsened, the number of newly differentiated genes gradually increased, among which the upregulated genes were found to be related to autophagy and NF-κB pathways, while the downregulated genes are associated with ...
美 英 un.细胞衰老 网络细胞老化;细胞衰老期 英汉 网络释义 un. 1. 细胞衰老 释义: 全部,细胞衰老,细胞老化,细胞衰老期
The transcriptional signature of cluster two was defined by the upregulation of both canonical senescence genes and overlapping gene signatures implicated in myeloid cell activation. This included upregulation of cyclin-dependent kinase inhibitors (Cdkn2a, Cdkn1a), senescence-related antiapoptotic factors (...