Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy,...
The senescence index of 3xDR microglia was 3.6-fold that of normal microglia (Extended Data Fig. 7d). Additionally, we compared cytoplasmic β-galactosidase (β-gal), a widely used marker of cell senescence, between control and 3xDR microglia. However, we did not observe β-gal elevation in...
In addition, we confirmed that BYHWD improves the prognosis of ICH by inhibiting Ctsb and enhancing cell autophagy.Availability of data and materials The data used to support the findings of this study are available from the corresponding author upon request....
, and/or serrations extending into the crypt base Proliferation may be abnormally located away from the crypt base, variable from crypt to crypt Small basally located nuclei with occasional larger nuclei with inconspicuous nucleoli, no dysplasia Mixed Micro-vesicular and Goblet cell >90% 0–5% ++...
We searched the database for genes previously shown to be involved in rose scent biosynthesis (Figure 4C; Additional file 4: Table S2). Transcripts coding for the putative germacrene-D synthase (RcGDS) accumulated at high levels during flower opening and senescence (OFT and SEN samples) while ...
Besides, sorafenib could also induce apoptosis, autophagy, and cell cycle arrest, but we could only obtain the IC50 of this ferroptosis inducer in the clinic database GDSC. Although ferroptosis provides us with an alternative to cancer therapy, the acquired resistance to it could be expected in ...
Cell 163, 1011–1025 (2015). Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519–525 (2012). Shamma, A. et al. Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras iso...
Stromal-epithelial interactions play a fundamental role in tissue homeostasis, controlling cell proliferation and differentiation. Not surprisingly, aberrant stromal-epithelial interactions contribute to malignancies. Studies of the cellular and molecula
We applied the nearest neighbor method to the crop layer raster, acquired through the RF approach (Section 2.3.1) to resample the data from 250 m to 30 m. The high-resolution cells were assigned the same values as the cell within which they are located, following the standard nearest ...
In mollusca, the developmental (embryonic, larval, and metamorphic) transcriptome ofA. californica[46] and maternal (1 to 2 cell and ~ 32 cell) transcriptome ofL. stagnalishave been conducted [47]. These studies shed novel insights into conserved sets of genes and pathways in early develop...