Single-cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)doi:10.3892/ijmm.2023.5326Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration, secondary bone hyperplasia, inadequate extracellular matrix ...
et al. Mechanisms of diabetes-induced endothelial cell senescence: role of arginase 1. Int. J. Mol. Sci. 19, 1215 (2018). Article Google Scholar Kiss, T. et al. Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain. Geroscience 42, ...
Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients. Immunity 53, 685–696 e683 (2020). Article CAS PubMed PubMed Central Google Scholar Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics ...
关键词: cancer aging single-cell sequencing gene expression transcriptomics next-generation sequencing senescence cancer aging single-cell sequencing gene expression transcriptomics next-generation sequencing senescence DOI: 10.3390/cells10113126 年份: 2021 ...
Subsequently, 31 of these deleterious mutations were validated by Sanger sequencing (Tables 5,6 and 7, Additional file 1: Tables S5-S9). Among these 31 mutations, only 7 of them were shared by multiple strains (Table 5), whereas the other 24 mutations were detected in only a single ...
Sequencing of endpoint plasma from our xenograft models revealed smaller human (tumor) DNA fragments than host mouse DNA (data not shown), as previously reported (Thierry et al., 2010; Mouliere et al., 2018). Future work could use these methods to investigate the effect of cell type, ...
“cell death” and “regulation of hydrogen peroxide metabolic process”. We also found many biological process terms related to hormones such as “salicylic acid mediated signaling pathway”, “jasmonic acid mediated signaling pathway”, “response to ethylene stimulus”, “response to abscisic acid ...
Animal experiments demonstrated that MSOH hydrogel showed better cartilage repairing effects and better maintained joint function at 24 weeks with low intra-articular inflammatory response after transplantation in rat joint.Single-cell RNA-seq of generated cartilage indicated that implanted MSOH could affect...
The introduction of single-cell RNA sequencing (scRNA-seq) has enabled the transformative advancement in our understanding of the intricate functional diversity of disorder development much like the comprehensive atlases created in other fields such as cancer7and neurological disorders8. In a substantial...
proinflammatory cytokines such as IL-6 and IL-8 increases after AKI [132,133]. Single-cell transcriptomic analysis has revealed that Vcam1 + /Ccl2+ RTECs at a late injury stage (28 days) can be distinguished by the activation of NF-κB, TNF, and AP-1 signaling pathways. These ...