Dormancy • Quiescence • Cellular senescence • HibernationDormant tumors are defined as microscopic (diameter of 1 mm) human cancers, either primary, recurrent or metastatic, and can remain in an asymptomatic, non-detectable, and occult form for a long period of time. In other words, ...
Covering virtually all aspects of cellular quiescence, including that of hematopoietic stem cells, the books represent the sum of current knowledge on the topic and explores the potential of techniques such as the removal of senescence cells that disrupt tissue structure and replicate irreparable double...
Most of us have cancer tumors, but by no means all of them will develop into cancer. Uncertainty remains about the factors that regulate entry of residual ...
falciparum, showing its highly unique composition carrying features of both cellular quiescence and senescence. We also demonstrate that the induced dormant forms require ~5 days of maturation, after which the resulting day 5 mature dormant persisters (d5MDP) exhibit resilience to a broad spectrum of...
Cellular senescence is a process that is mainly designed to eliminate unwanted cells by inducing tissue remodelling. In general, cellular senescence promotes tissue remodelling through three sequential processes: a stable proliferative arrest; a secretory phenotype (SASP) that recruits immune cells and mod...
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the ident...
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling molecules that poison surrounding cells, leading to various age-related diseases, including diabetes, atherosclerosis, and Alzheimer’s disease. The underlying mechanism of cellular senescence has not yet been fully explored...
Which markers are used to identify senescence? Studying senescence as researchers presents problems, as there is no single marker for use in identifying this state. Senescent cells are metabolically active but do not divide, and though they are distinct from cells in quiescence, as both are post...
Which markers are used to identify senescence? Studying senescence as researchers presents problems, as there is no single marker for use in identifying this state. Senescent cells are metabolically active but do not divide, and though they aredistinct from cells in quiescence, as both are post-...
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to cancer development and age-related diseases. Cellular senescence involves cell-cycle arrest and the release of inflammatory cyt...