Dormancy • Quiescence • Cellular senescence • HibernationDormant tumors are defined as microscopic (diameter of 1 mm) human cancers, either primary, recurrent or metastatic, and can remain in an asymptomatic, non-detectable, and occult form for a long period of time. In other words, ...
Covering virtually all aspects of cellular quiescence, including that of hematopoietic stem cells, the books represent the sum of current knowledge on the topic and explores the potential of techniques such as the removal of senescence cells that disrupt tissue structure and replicate irreparable double...
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Cellular senescence is a process that is mainly designed to eliminate unwanted cells by inducing tissue remodelling. In general, cellular senescence promotes tissue remodelling through three sequential processes: a stable proliferative arrest; a secretory phenotype (SASP) that recruits immune cells and mod...
Characterization of Cellular Senescence Senescent cells differ from other states ofcell cycle arrest, such as quiescence or terminal differentiation, by distinctive but not exclusive markers and morphological changes. A flattened and enlarged morphology with increased cellular granularity is generally observed...
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to cancer development and age-related diseases. Cellular senescence involves cell-cycle arrest and the release of inflammatory cyt...
Between these extremes, cells can acquire other states, often associated with survival but also with permanent structural and functional changes. An example is the non-proliferative but viable state, distinct from G0 quiescence and terminal differentiation, termed cellular senescence (Rodier and Campisi,...
Which markers are used to identify senescence? Studying senescence as researchers presents problems, as there is no single marker for use in identifying this state. Senescent cells are metabolically active but do not divide, and though they aredistinct from cells in quiescence, as both are post-...
Which markers are used to identify senescence? Studying senescence as researchers presents problems, as there is no single marker for use in identifying this state. Senescent cells are metabolically active but do not divide, and though they are distinct from cells in quiescence, as both are post...
Tumorigenesis is s a multistage process characterized by multiple genetic and molecular insults. The progression from premalignancy to malignancy requires bypass of tumor suppressor mechanisms such as apoptosis and cellular senescence. While apoptosis ha