This study aims to investigate the prognostic significance of senescence-related genes in breast cancer. We utilized the SenMayo gene list, a comprehensive set of senescence-related genes, to analyze gene expression data from a large cohort of breast cancer samples. The data was sourced from the...
genes (CNOT6, DNMT3B, MAP2K1, TBPL1, andSREBF1), 18 DNA methylation genes, and LAYN protein expression which were all causally associated with different cancer types. Beyond causality, a comprehensive analysis of gene function, pathways, and druggability values was also conducted. These finding...
Further analyses indicated that GDS1 binds to the promoters of several senescence-related genes, including Phytochrome-Interacting Transcription Factors 4 and 5... H Fan,S Quan,Ye, QingZhang, LeiLiu, WeiZhu, NingZhang, XiaoqiRuan, WenyuanYi, KekeCrawford, Nigel M.Wang, Yong - 《Molecular Plant...
A similar pattern was observed in the setting of diverse solid malignancies –the presence of CH in presumptive leukemia driver genes (CH-PD) was associated with both a shorter survival and a subsequent increase in hematological neoplasms. This finding, however, is not universal—a similarly ...
thesedatasuggesttheoperationofcertainsenescence-associatedfunctionalnuclearbarriersbydown-regulationofthenucleo-cytoplasmictraffickinggenesinthesenescentcells.Ó2009ElsevierInc.Allrightsreserved.IntroductionSenescenthumandiploidfibroblasts(HDFs)showseveralcharac-teristicfeatureswhencomparedtoyoungHDFssuchasthedistinct...
with recent data showing the increased expression of senescence markers in brain regions of these mice [59]. Additionally, recent reports suggested a causal relationship between shorter telomeres and AD risk [102]. Supporting this idea, genetic variations in genes involved in telomere maintenance have...
A large number of experimental results indicated that cells in leaf se- lectively to switch on or enhanced genes expression and also to close or weaken its correlation genes expression in order to control aging process of leaf. Now scientists had discovered a lot of leaf senescence associated ...
Of note, the patterns of evolutionary conservation of CS and cancer genes showed a high degree of similarity, suggesting the co-evolution of these two phenomena. Moreover, cancer genes and microRNAs seem to stand at the crossroad between CS and ARDs. Our analysis also provides the basis for ...
Up-regulation of cell cycle regulatory genes after renal ischemia/reperfusion: differential expression of p16(INK4a), p21(WAF1/CIP1) and p27(Kip1) cyclin-dependent kinase inhibitor genes depending on reperfusion time. Transpl. Int. 19, 72–77 (2006). Article CAS PubMed Google Scholar Chk...
We also found that 9/13-HODEs activated the key transcription factor SREBP1 and upregulated several important genes associated with hepatic steatosis. We found that both induced steatosis when we treated hepatocytes with 9-HODE and 13-HODE. SREBP1 was activated by 13-HODE but not by 9-HODE....