To uncover the role of senescence in gliomas, we collected senescence-related genes for integrated analysis. Consensus clustering was used to subtype gliomas based on the senescence gene set, and we identified two robust prognostic clusters of gliomas with distinct survival outcomes, multi-omics ...
25,26], has been linked to age-related functional decline and the pathogenesis of diseases, emphasizing the far-reaching impact of senescence on overall health. In breast cancer, the role of senescence-related genes and cellular
Identification of senescence-related genes by cDNA-AFLP in cotton (Gossypium hirsutum L.).Practical/ cottonDNAgenetic engineeringgeneticsphotosynthesispolymorphism/ senescence-related gene identificationcDNA-AFLPGossypium hirsutum Lpremature senescenceNorth China...
50 Views 0 CrossRef citations to date 0 Altmetric ORIGINAL RESEARCH Identification of Senescence-Related Genes for the Prediction of Ulcerative Colitis Based on Interpretable Machine Learning Models Jingjing Ma, Chen Chen, Nian Wang, Ting Fang, Yinghui Liu, Pengzhan He & show all Pages...
We aim to screen key genes associated with cellular senescence (CS) in CAVD. Methods : The GSE12644 and GSE51472 datasets from the GEO database was utilized in this study, and differentially expressed genes (DEGs) were identified using the "limma" R package. CS-rela...
nucleo-cytoplasmictraffickinggenesinthesenescentcells. Ó2009ElsevierInc.Allrightsreserved. Introduction Senescenthumandiploidfibroblasts(HDFs)showseveralcharac- teristicfeatureswhencomparedtoyoungHDFssuchasthedistinct flatandenlargedmorphology[1,2];appearanceofsenescence-asso- ciatedb-galactosidaseactivity[...
We also found that 9/13-HODEs activated the key transcription factor SREBP1 and upregulated several important genes associated with hepatic steatosis. We found that both induced steatosis when we treated hepatocytes with 9-HODE and 13-HODE. SREBP1 was activated by 13-HODE but not by 9-HODE....
Up-regulation of cell cycle regulatory genes after renal ischemia/reperfusion: differential expression of p16(INK4a), p21(WAF1/CIP1) and p27(Kip1) cyclin-dependent kinase inhibitor genes depending on reperfusion time. Transpl. Int. 19, 72–77 (2006). Article CAS PubMed Google Scholar Chk...
Interestingly, there are ambiguities in the effect of SIRT1 on FOXO activity with variations according to gene or function; SIRT increases transcription of genes involved in cell cycle arrest and resistance to oxidative stress and represses genes promoting FOXO-dependent cell death [201]. Similar to...
Higher expression of senescence-related genes and an increased number of SA-β-gal+ cells were detected in the SSPCs transfected with Plxnb2 siRNA relative to control siRNA-treated SSPCs (Fig. 5i–l and Fig. S5d). We then examined whether knockdown of Plxnb2 would lead to the diminished ...