However, models to predict the prognosis of melanoma based on senescence-related lncRNAs and the efficacy of immune checkpoint therapy remain undefined. In this study, we developed a predictive signature consisting of four senescence-related lncRNAs (AC009495.2, U62317.1, AATBC, MIR205HG), ...
Other not less relevant senescence-related metabolic changes such as NH 4 accumulation and the oxidative burst are beyond the scope of this review. 展开 关键词: Apoplast Extracellular proteome Leaf senescence Programmed cell death Transporter proteins ...
senescencenucleocytoplasmicnuclearregulationexpression Senescence-relatedfunctionalnuclearbarrierbydown-regulationofnucleo-cytoplasmictraffickinggeneexpressionSungYoungKima,SungJinRyua,HongJuAhna,HaeRiChoia,HyunTaeKanga,SangChulParka,*aDepartmentofBiochemistryandMolecularBiology,AgingandApoptosisResearchCenter,InstituteonAging...
Lipid changes related to abscisic acid (ABA) induced senescence was studied in callus cultures of Datura innoxia. Cultures attained terminal senescence in four weeks due to supplementation of ABA. Senescence was marked by loss of chlorophyll, decrease in protein content and profound changes in lipid...
Background: Dystrophic neurites are associated with 尾-amyloid (A尾) plaques in the brains of Alzheimer's disease (AD) and also found to be common in some specific areas of the normal aged brains. Methods: We immunostained brain sections from young to old mice with some putative markers. ...
Further analyses indicated that GDS1 binds to the promoters of several senescence-related genes, including Phytochrome-Interacting Transcription Factors 4 and 5... H Fan,S Quan,Ye, QingZhang, LeiLiu, WeiZhu, NingZhang, XiaoqiRuan, WenyuanYi, KekeCrawford, Nigel M.Wang, Yong - 《Molecular Plant...
Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Leveln of Advanced Glycated End Produc... Cho, "Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Level of Advanced ...
Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we
The team's next step will be to determine whether the uPAR-directed CAR T cells can effectively combat other senescence-related diseases, including atherosclerosis, diabetes, and osteoarthritis. Eventually, they hope to develop the cells for clinical use in people. ...
Therefore, SAM(SAMP,SAMR) provides a good model for clarifing the pathogenic mechanism of senescence and senescence related disease, and evaluating the efficiency of drugs and their mechanisms. 展开 关键词: senescence accelerated mouse (SAM senescence murine model ...