Terminin is a cytoplasmic protein expressed in irreversibly growth-arrested senescent fibroblast cultures and in terminally differentiated cells of various epithelia. In the present study, terminin was identified by immunohistochemistry in the cytoplasm of neurons and glia of aging rat brain using the ...
Conclusions: Thus, aging-associated disturbances of UPR and accumulation of protein aggregates at cholinergic nerve terminals in specific areas of brain regions related with memory could be associated with normal decline of memory in aged people. In addition, these age-related changes might be the ...
Lipid changes related to abscisic acid (ABA) induced senescence was studied in callus cultures of Datura innoxia. Cultures attained terminal senescence in four weeks due to supplementation of ABA. Senescence was marked by loss of chlorophyll, decrease in protein content and profound changes in lipid...
To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young...
a–c HepG2 cells were treated with 500 μM H2O2 for 48 h to induce senescent hepatocytes: 9-HODE and 13-HODE levels in control and senescent hepatocytes (a) and in the conditioned medium from these cells (b); (c) Western blot analysis of the protein level of ALOX15 in control ...
perspective.Three characteristic genes were identified and a senescence-based nomogram was constructed for DCM diagnosis.Immune cell infiltration analysis suggested dysregulation of inflammation in DCM.Molecular docking indicated that chlorogenic acid could directly bind to the active pocket of MME protein.关...
Mechanistically, we identified sEVs to have intrinsic glutathione-S-transferase activity partially due to the high levels of expression of the glutathione-related protein (GSTM2). Transfection of recombinant GSTM2 into sEVs derived from old fibroblasts restores their antioxidant capacity. sEVs increase...
Senescence-relatedfunctionalnuclearbarrierbydown-regulationofnucleo-cytoplasmictraffickinggeneexpressionSungYoungKima,SungJinRyua,HongJuAhna,HaeRiChoia,..
Using systems biology tools, we found that CS is closely interconnected with aging, longevity and ARDs, either by sharing common genes and regulators or by protein-protein interactions and eventually by common signaling pathways. The most enriched pathways across CS, ARDs and aging-associated ...
Alteration of protein expression controlled by Smad3 was examined using a proteomic analysis. CCl4-induced liver fibrosis was rarely detected inSmad3/mice compared toSmad3+/+. Proteomic analysis revealed that proteins related to antioxidant activities such as senescence marker protein-30 (SMP30), ...