Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell. Signal. 24, 835–845 (2012). Article CAS PubMed Google Scholar Nelson, G. et al. A senescent cell bystander effect: senescence-induced senescence. Aging Cell 11, 345–349 (2012...
However, lingering senescent cells fuel chronic inflammation through the acquisition of a senescence-associated secretory phenotype (SASP), which contributes to cancer and age-related tissue dysfunction. Recent progress in understanding senescence has spurred interest in the development of approaches to ...
47,48]. Such an activation eventually leads to an enhanced secretion of cytokines, chemokines, proteases and ROS by senescent cells [49], collectively termed as the senescence-associated secretory phenotype (SASP) [9,50]. This could be
Cellular senescence is traditionally defined as permanent cell growth arrest and currently includes the senescence-associated secretory phenotype (SASP). There are two main types of cellular senescence, including telomere-dependent replicative senescence and stress-induced premature senescence. The process of...
The senescent cell became a major actor of the aging process, among others, by the acquisition of the senescence-associated secretory phenotype. This chapter is devoted to the regulatory process involved in the acquisition of the senescent cell phenotype and its role in organismal aging. 展开 关键...
However, senescent cells display a pro-inflammatory phenotype, called the senescence-associated secretory phenotype (SASP), which is a common characteristic of senescent cells (Section 3). Single cell analyses of senescent cells have revealed that there exists significant cell-to-cell variability among...
The above mentioned destructive effects do not lead to aging right away, it is the accumulative effect of damage that leads to cell growth arrest and the “senescence-associated secretory phenotype” (SASP), a hallmark of senescence through which cells transform fibroblasts into pro-inflammatory cyto...
One of the hallmarks of aging is the accumulation of senescent cells; as in almost all tissues, also the cells of bone acquire a “senescence-associated secretory phenotype” (SASP). Since components of the SASP are involved in the pathophysiology of age-related osteoporosis, cellular senescence ...
Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth mu... Rationale: Vascular calcification is prevalent in the aging population, yet little is known of the mechanisms driving age-associated vascular smooth...
展开 关键词: extracellular vesicles EV senescence aging senescence-associated secretory phenotype SASP glutathione-S-transferase GST lipid peroxidation rejuvenation ROS 4-HNE glutathione metabolism GSH DOI: 10.1016/j.cmet.2020.06.004 年份: 2020 收藏 引用 批量引用 报错 分享 全部...