et al. Unmasking transcriptional heterogeneity in senescent cells. Curr. Biol. 27, 2652–2660 (2017). CAS PubMed PubMed Central Google Scholar Wiley, C. D. et al. Analysis of individual cells identifies cell-to
et al. Unmasking transcriptional heterogeneity in senescent cells. Curr. Biol. 27, 2652–2660 (2017). Article CAS PubMed PubMed Central Google Scholar Faget, D. V., Ren, Q. & Stewart, S. A. Unmasking senescence: context-dependent effects of SASP in cancer. Nat. Rev. Cancer 19, 439...
CSCs are not a static identity in tumoral heterogeneity, as they are considered a cellular state. Cells in the tumor are differentiated and dedifferentiated to this cellular state, and the tumor microenvironment plays an essen- tial role. For example, it has been demonstrated that CSCs can ...
Outline Highlights Abstract Keywords 1. Ageing of the skin 2. Cellular senescence 3. Evidence for a role of cell senescence in intrinsic skin ageing 4. Conclusions and open questions Funding ReferencesShow full outline Cited by (62) Figures (3) Tables (3) Table 1 Table 2 Table 3...
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the heterogeneity of prostate cancer. Tumour-associated ep...
Treatment with YQHX decreased the extent of microtubule structure damage, the fluorescence intensity in these cells was much higher than that observed in the M group and the heterogeneity of staining and nuclear fragmentation were also greatly alleviated. This indicates that YQHX enhances microtubule ...
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the heterogeneity of prostate cancer. Tumour-associated ep...
Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P,et al. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci. 2013;126(24):5553–65.https://doi.org/10.1242/jcs.128868. ...
Drug-induced tumor heterogeneity Another important factor that might lead to MDR is intra-tumor heterogeneity. Resistance might result from the Darwinian selection of preexisting cell states, where epithelial or mesenchymal properties are increased or acquired through epigenetic adaptation (EMT). Notably,...
It has been demonstrated that metabolic heterogeneity exists in tumors with different metabolic phenotypes such as aerobic glycolysis and OXPHOS in a certain type of cell [219, 220]. A portion of cancer cells and CAFs show a glycolytic phenotype, while other cancer cells utilize lactate as an en...