Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy,...
et al. Unmasking transcriptional heterogeneity in senescent cells. Curr. Biol. 27, 2652–2660 (2017). CAS PubMed PubMed Central Google Scholar Wiley, C. D. et al. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16, 1043...
molecules (NCAM) to invade cells [27]. In addition, mosquitoes, which are the primary transmission vectors of flaviviruses, can exploit the GABAergic system to suppress natural immunity and facilitate virus infection [28]. Previous studies have demonstrated that JEV primarily targets specific regions ...
Drug-induced tumor heterogeneity Another important factor that might lead to MDR is intra-tumor heterogeneity. Resistance might result from the Darwinian selection of preexisting cell states, where epithelial or mesenchymal properties are increased or acquired through epigenetic adaptation (EMT). Notably,...
In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demonstrated unprecedented potential in the treatment of POF. However, the heterogeneity of human UC-MSCs remains a challenge for their large-scale clinical application. Therefore, it is imperative to...
It has been demonstrated that metabolic heterogeneity exists in tumors with different metabolic phenotypes such as aerobic glycolysis and OXPHOS in a certain type of cell [219, 220]. A portion of cancer cells and CAFs show a glycolytic phenotype, while other cancer cells utilize lactate as an en...
AS is known as a complicated regulatory process by which diverse mature RNA isoforms are generated from one pre-mRNA, which potentially results in the structural heterogeneity of the gene products [36]. AS is also highly involved in both chondrogenesis and hypoxia-induced biological activities [13...
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of the mechanisms of tumor development. Single-cell technologies have also been used to identify pot...
et al. Unmasking transcriptional heterogeneity in senescent cells. Curr. Biol. 27, 2652–2660 (2017). Article CAS PubMed PubMed Central Google Scholar Faget, D. V., Ren, Q. & Stewart, S. A. Unmasking senescence: context-dependent effects of SASP in cancer. Nat. Rev. Cancer 19, 439...
For further investigation, we performed high-resolution subclustering analysis to uncover the heterogeneity of these cell types. To reduce the effects of drastically different cell identities, we first grouped the identified cells into five distinct classes based on their expression profile, lineage, fun...